Document Detail


Importance of vagal input in maintaining gastric tone in the dog.
MedLine Citation:
PMID:  2888879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Using a gastric barostat to quantify variations in gastric tone, we had previously demonstrated that food ingestion or intestinal nutrient perfusion induces gastric relaxation. These data suggested a basal tonic contraction of the stomach during fasting. 2. To determine the role of vagal input in maintaining fasting gastric tone, we prepared two chronic canine models, either isolating both cervical vagal trunks in a cutaneous tunnel or including the supradiaphragmatic vagi within an implanted cooling jacket. In the fasted conscious dogs, we then studied the effect, on gastric tone, of acute and reversible vagal blockade by cooling. 3. Cervical vagal cooling produced a reversible gastric relaxation and increased the heart rate. Supradiaphragmatic vagal cooling produced a similar gastric relaxation without the cardiac effect. 4. Adrenergic blockade did not change either the base-line gastric tone or the cooling-induced relaxation. Adrenaline decreased gastric tone, but vagal cooling still produced a significant relaxation. 5. Atropine alone or combined with adrenergic antagonists produced a gastric relaxation that was not further increased by vagal cooling. Bethanechol increased gastric tone, an effect unchanged by vagal cooling. 6. We conclude that gastric tone during fasting is maintained by a cholinergic input, which is vagally mediated at both the cervical and the supradiaphragmatic levels.
Authors:
F Azpiroz; J R Malagelada
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of physiology     Volume:  384     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-11-16     Completed Date:  1987-11-16     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  511-24     Citation Subset:  IM    
Affiliation:
Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55905.
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MeSH Terms
Descriptor/Qualifier:
Animals
Atropine / pharmacology
Bethanechol
Bethanechol Compounds / pharmacology
Cold Temperature
Dogs
Epinephrine / pharmacology
Fasting
Heart Rate / drug effects
Muscle Relaxation
Muscle Tonus / drug effects
Stomach / physiology*
Sympatholytics / pharmacology
Vagus Nerve / physiology*
Grant Support
ID/Acronym/Agency:
AM-26428/AM/NIADDK NIH HHS; AM-34988/AM/NIADDK NIH HHS; RR-00585/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Bethanechol Compounds; 0/Sympatholytics; 51-43-4/Epinephrine; 51-55-8/Atropine; 674-38-4/Bethanechol
Comments/Corrections

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