Document Detail


Importance of topical hypothermia to ensure uniform myocardial cooling during coronary artery bypass.
MedLine Citation:
PMID:  6975405     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent reports have suggested that the delivery of cardioplegia to regional myocardium is impaired in patients with severe coronary artery disease. This study was designed to determine whether or not topical hypothermia is a necessary adjunct to systemic hypothermia and potassium cardioplegia to provide adequate cooling in regional myocardium supplied by stenotic or occluded coronary arteries. Twenty-two patients ranging in age from 47 to 68 years were included in the study. Patients were placed on bypass and cooled to 28 degrees C. Temperature was measured over the right and left coronary artery distributions. The aorta was then cross-clamped and 1,000 cc of potassium blood cardioplegia, 5.7 degrees to 11 degrees C (mean 8.7 degrees), was infused into the aortic root at a mean pressure of 99 mmHg. Temperature was measured and 6 L of cold electrolyte (Plasma-lyte) solution, 2.3 degrees to 5.1 degrees C (mean 3.5) was poured over the heart into the pericardial well. The temperature measurements were then repeated. Myocardial temperature in regional myocardium supplied by normal coronary arteries after the injection of cardioplegia was less than 15 degrees C. However myocardium distal to a severe stenosis or complete occlusion was significantly warmer (p less than 0.001). Topical hypothermia reduced myocardial temperature to less than 15 degrees C in regional myocardium supplied by severely diseased vessels (p less than 0.001). These data demonstrate that the combination of systemic hypothermia and potassium cardioplegia alone does not provide adequate myocardial cooling in patients with severe coronary artery disease and emphasize the need for intraoperative myocardial temperature monitoring to ensure optimal protection during the ischemic period.
Authors:
R W Landymore; D Tice; N Trehan; F Spencer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  82     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  1981 Dec 
Date Detail:
Created Date:  1982-01-28     Completed Date:  1982-01-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  832-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Body Temperature*
Coronary Artery Bypass*
Coronary Circulation
Coronary Disease / surgery
Heart / drug effects,  physiopathology*
Humans
Hypothermia, Induced / methods*
Middle Aged
Potassium / pharmacology
Chemical
Reg. No./Substance:
7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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