Document Detail

Importance of the surface area ratio on cytokines production by human monocytes in vitro induced by various hydroxyapatite particles.
MedLine Citation:
PMID:  15585239     Owner:  NLM     Status:  MEDLINE    
A possible complication associated with the implantation of hydroxyapatite (HA)-based prosthesis is the release of particles. Those particles can be phagocyted by monocytes that are among the first cells to colonize the inflammatory site. The activated monocytes produce inflammatory mediators, such as cytokines, which cause osteoclasts activation. It has previously been demonstrated using a surface area ratio (ratio of the total surface of the given particles to the surface area of cells) of 1 to 1 that there was a correlation between the expression and production of cytokines induced by HA. The present work studies the effect of physical characteristics of HA particles on the production of various inflammatory cytokines (tumour necrosis factor-alpha, interleukin (IL)-6, and IL-8) and anti-inflammatory cytokine (IL-10). However, the experiments were performed using a surface area ratio of 10 to 1. Our data demonstrate that all the particles, whatever their characteristics, induced a high expression of cytokines but the production was different, meaning that there was a post-transcriptional regulation. The size and sintering temperature seemed to be a characteristics that were less important compared to the shape; the needle particles appeared to induce the most important production of all the cytokines studied.
Alexia Grandjean-Laquerriere; Patrice Laquerriere; Moncef Guenounou; Dominique Laurent-Maquin; Terry M Phillips
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Biomaterials     Volume:  26     ISSN:  0142-9612     ISO Abbreviation:  Biomaterials     Publication Date:  2005 May 
Date Detail:
Created Date:  2004-12-08     Completed Date:  2005-06-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  England    
Other Details:
Languages:  eng     Pagination:  2361-9     Citation Subset:  IM    
Ultramicro Analytical Immunochemistry Resource, Division of Bioengineering and Physical Science, Office of Research Services, National Institutes of Health, Bethesda, MD 20892, USA.
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MeSH Terms
Biocompatible Materials / adverse effects*
Cells, Cultured
Cytokines / immunology*,  metabolism
Dose-Response Relationship, Drug
Durapatite / adverse effects*
Materials Testing
Monocytes / drug effects*,  immunology*,  metabolism
Particle Size
Surface Properties
Reg. No./Substance:
0/Biocompatible Materials; 0/Cytokines; 1306-06-5/Durapatite

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