Document Detail

Importance of the replication origin sequestration in cell division of Escherichia coli.
MedLine Citation:
PMID:  8824767     Owner:  NLM     Status:  MEDLINE    
The DNA adenine methyltransferase of Escherichia coli methylates adenines at GATC sequences. The mutant deficient in this methylase has no apparent deficiency in the cell division process in spite of the absence of both synchrony in initiations of chromosomal DNA replication and sequestration of replication origin (oriC) at hemimethylated state. However, the dam mutant cannot resume cell division after hyperosmotic shock differing from the wild-type strain. This inhibition is not provoked by induction of the cell division inhibitor, SfiA protein. Although the FtsZ protein is present in the dam mutant in a reduced amount compared to wild-type, the quantitative difference of this protein is not the main reason of division arrest provoked by hyperosmotic shock. This observation supports the idea of oriC-membrane interaction playing a role both in chromosome partitioning and cell division as predicted by replicon theory.
J Meury; A Bahloul; M Kohiyama
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimie     Volume:  77     ISSN:  0300-9084     ISO Abbreviation:  Biochimie     Publication Date:  1995  
Date Detail:
Created Date:  1996-12-05     Completed Date:  1996-12-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1264604     Medline TA:  Biochimie     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  875-9     Citation Subset:  IM    
Biochimie Génétique, Université Paris, France.
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MeSH Terms
Bacterial Proteins / genetics,  metabolism*
Betaine / pharmacology
Cell Division
Cytoskeletal Proteins*
DNA, Bacterial / genetics*
Escherichia coli / genetics*,  growth & development*
Escherichia coli Proteins*
Replication Origin / physiology*
Reg. No./Substance:
0/Bacterial Proteins; 0/Cytoskeletal Proteins; 0/DNA, Bacterial; 0/Escherichia coli Proteins; 0/FtsZ protein, Bacteria; 0/sulA protein, E coli; 107-43-7/Betaine

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