| Importance of renin in blood pressure regulation and therapeutic potential of renin inhibition. | |
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MedLine Citation:
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PMID: 16700858 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite improvements in its detection and treatment, hypertension remains a significant public health problem worldwide. In recent years, many international hypertension societies and organisations have set increasingly rigorous blood pressure (BP) targets, with the aim of reducing cardiovascular complications, and this has in turn necessitated the use of more antihypertensive medications to reach these targets in individual patients. There is therefore an ongoing need to develop antihypertensive drugs with new mechanisms of action. Renin inhibitors represent a novel class of compounds which offer considerable promise as BP-lowering agents. Here, we review the rationale for renin inhibition as a therapeutic target and examine the preclinical and clinical evidence for the antihypertensive effectiveness of the renin inhibitors. |
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Authors:
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A Ferro; R Gilbert; H Krum |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: International journal of clinical practice Volume: 60 ISSN: 1368-5031 ISO Abbreviation: Int. J. Clin. Pract. Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-05-16 Completed Date: 2006-07-25 Revised Date: 2007-02-14 |
Medline Journal Info:
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Nlm Unique ID: 9712381 Medline TA: Int J Clin Pract Country: England |
Other Details:
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Languages: eng Pagination: 577-81 Citation Subset: IM |
Affiliation:
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Department of Clinical Pharmacology, Cardiovascular Division, GKT School of Medicine, King's College London, London, UK. albert.ferro@kcl.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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therapeutic use Blood Pressure / physiology* Humans Hypertension / drug therapy*, physiopathology Renin / antagonists & inhibitors, physiology* Renin-Angiotensin System / physiology |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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