Document Detail


Importance of renin in blood pressure regulation and therapeutic potential of renin inhibition.
MedLine Citation:
PMID:  16700858     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite improvements in its detection and treatment, hypertension remains a significant public health problem worldwide. In recent years, many international hypertension societies and organisations have set increasingly rigorous blood pressure (BP) targets, with the aim of reducing cardiovascular complications, and this has in turn necessitated the use of more antihypertensive medications to reach these targets in individual patients. There is therefore an ongoing need to develop antihypertensive drugs with new mechanisms of action. Renin inhibitors represent a novel class of compounds which offer considerable promise as BP-lowering agents. Here, we review the rationale for renin inhibition as a therapeutic target and examine the preclinical and clinical evidence for the antihypertensive effectiveness of the renin inhibitors.
Authors:
A Ferro; R Gilbert; H Krum
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of clinical practice     Volume:  60     ISSN:  1368-5031     ISO Abbreviation:  Int. J. Clin. Pract.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-16     Completed Date:  2006-07-25     Revised Date:  2007-02-14    
Medline Journal Info:
Nlm Unique ID:  9712381     Medline TA:  Int J Clin Pract     Country:  England    
Other Details:
Languages:  eng     Pagination:  577-81     Citation Subset:  IM    
Affiliation:
Department of Clinical Pharmacology, Cardiovascular Division, GKT School of Medicine, King's College London, London, UK. albert.ferro@kcl.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Antihypertensive Agents / therapeutic use
Blood Pressure / physiology*
Humans
Hypertension / drug therapy*,  physiopathology
Renin / antagonists & inhibitors,  physiology*
Renin-Angiotensin System / physiology
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; EC 3.4.23.15/Renin

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