Document Detail

Importance of the renin-angiotensin system in the generation of kidney failure in renovascular hypertension.
MedLine Citation:
PMID:  8986915     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To determine the possible relationship between the degree of dietary sodium intake and the development of renal failure during blockade of the renin-angiotensin system. DESIGN: Antihypertensive doses of captopril, an angiotensin converting enzyme, and hydralazine, a non-specific vasodilator, were administered in sham-operated and two-kidney, two clip Goldblatt hypertensive rats subjected to various degrees of dietary sodium intake. METHODS: The blood pressure, water intake, urine flow and sodium excretion of the animals were determined before and during a 3-day period of drug administration. Plasma concentrations of urea and creatinine were measured as indicators of renal function and glomerular filtration rate. RESULTS: The blood pressure of the clipped rats was higher than that of sham-operated rats (241 +/- 5 versus 150 +/- 4 mmHg), regardless of their sodium intake. Captopril administration failed to lower blood pressures of sodium-replete hypertensive rats, but in hypertensive rats fed either a low- or a 'no'-sodium diet the blood pressure was reduced by 45 +/- 7 and 127 +/- 19 mmHg, respectively. Furthermore, hydralazine reduced blood pressure in hypertensive rats fed a 'no'-sodium diet by a similar degree, to 99 +/- 8 mmHg. Captopril, but not hydralazine, significantly increased plasma levels of urea and creatinine in hypertensive rats fed the 'no'-sodium diet. CONCLUSION: These findings indicate that angiotensin II plays an important role in the maintenance of renal function during blood pressure reduction by angiotensin converting enzyme inhibition in volume-contracted renovascular hypertensive states.
A Abdi; E J Johns
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  14     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-03-20     Completed Date:  1997-03-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1131-7     Citation Subset:  IM    
Department of Physiology, Medical School, Birmingham, UK.
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MeSH Terms
Angiotensin II / physiology
Blood Pressure / drug effects
Captopril / pharmacology
Hypertension, Renovascular / physiopathology*
Kidney Failure / etiology*
Rats, Wistar
Renin-Angiotensin System / physiology*
Sodium, Dietary / administration & dosage
Reg. No./Substance:
0/Sodium, Dietary; 11128-99-7/Angiotensin II; 62571-86-2/Captopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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