| Importance of the renin-angiotensin-aldosterone system (RAS) in the physiology and pathology of hypertension. An overview. | |
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MedLine Citation:
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PMID: 2188822 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Current leading theories of the mechanisms of essential hypertension include the participation of the renin-angiotensin-aldosterone system (RAS). Recent advances provide means for a critical reassessment of this system in the physiology and pathology of hypertension. The expression of the proteins of the RAS in organs other than the kidneys suggests that angiotensin II also acts as a modulator of cell function. This paper discusses the role of tissue angiotensin peptides in the regulation of blood pressure and suggests new ideas with regard to the importance of the brain RAS in the development of essential hypertension. |
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Authors:
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C M Ferrario |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Drugs Volume: 39 Suppl 2 ISSN: 0012-6667 ISO Abbreviation: Drugs Publication Date: 1990 |
Date Detail:
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Created Date: 1990-06-29 Completed Date: 1990-06-29 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7600076 Medline TA: Drugs Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1-8 Citation Subset: IM |
Affiliation:
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Department of Brain and Vascular Research, Cleveland Clinic, Ohio. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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metabolism* Animals Brain / metabolism* Humans Hypertension / physiopathology* Renin-Angiotensin System / physiology* |
| Chemical | |
Reg. No./Substance:
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11128-99-7/Angiotensin II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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