Document Detail

Importance of the renin-angiotensin-aldosterone system (RAS) in the physiology and pathology of hypertension. An overview.
MedLine Citation:
PMID:  2188822     Owner:  NLM     Status:  MEDLINE    
Current leading theories of the mechanisms of essential hypertension include the participation of the renin-angiotensin-aldosterone system (RAS). Recent advances provide means for a critical reassessment of this system in the physiology and pathology of hypertension. The expression of the proteins of the RAS in organs other than the kidneys suggests that angiotensin II also acts as a modulator of cell function. This paper discusses the role of tissue angiotensin peptides in the regulation of blood pressure and suggests new ideas with regard to the importance of the brain RAS in the development of essential hypertension.
C M Ferrario
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Drugs     Volume:  39 Suppl 2     ISSN:  0012-6667     ISO Abbreviation:  Drugs     Publication Date:  1990  
Date Detail:
Created Date:  1990-06-29     Completed Date:  1990-06-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7600076     Medline TA:  Drugs     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
Department of Brain and Vascular Research, Cleveland Clinic, Ohio.
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MeSH Terms
Angiotensin II / metabolism*
Brain / metabolism*
Hypertension / physiopathology*
Renin-Angiotensin System / physiology*
Reg. No./Substance:
11128-99-7/Angiotensin II

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