Document Detail


Importance of pulsing illumination parameters in low-level-light therapy.
MedLine Citation:
PMID:  20799848     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The influence of emission parameters in low-level-light therapy on cellular responses is not yet fully understood. This study assessed the impact of various light delivery modes on collagen production in human primary fibroblast cultured in monolayers after three treatments with red light-emitting diode illumination (630 nm, 8 J/cm(2)). Human type I collagen was measured in cell culture supernatants with procollagen type I C-peptide enzyme immunoassay. Results demonstrated that, 72 h post-baseline, specific microsecond pulsing patterns had a more favorable impact on the ability of fibroblasts to produce collagen de novo than comparative conditions of continuous wave, pulsed 50% duty cycle, and millisecond pulsing domains. The cascade of events leading to collagen production by red illumination may be explained by the photodissociation of nitric oxide from cytochrome c oxidase. Short and intermittent light delivery might enhance this cellular event.
Authors:
Daniel Barolet; Pascale Duplay; Hélène Jacomy; Mathieu Auclair
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomedical optics     Volume:  15     ISSN:  1560-2281     ISO Abbreviation:  J Biomed Opt     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-08-30     Completed Date:  2011-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9605853     Medline TA:  J Biomed Opt     Country:  United States    
Other Details:
Languages:  eng     Pagination:  048005     Citation Subset:  IM    
Affiliation:
RoseLab Skin Optics Laboratory, Montreal, Quebec, Canada. daniel.barolet@mcgill.ca
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MeSH Terms
Descriptor/Qualifier:
Cell Line
Collagen Type I / metabolism*
Fibroblasts / physiology*,  radiation effects*
Humans
Laser Therapy, Low-Level*
Lighting / methods*
Chemical
Reg. No./Substance:
0/Collagen Type I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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