Document Detail


Importance and prevention of malaria in pregnancy.
MedLine Citation:
PMID:  12886801     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Malaria in pregnancy is one of the most important preventable causes of low birthweight deliveries worldwide. It is also a major cause of severe maternal anaemia contributing to maternal mortality. It is estimated that 40% of the world's pregnant women are exposed to malaria infection during pregnancy. The clinical features of Plasmodium falciparum malaria in pregnancy depend to a large extent on the immune status of the woman, which in turn is determined by her previous exposure to malaria. In pregnant women with little or no pre-existing immunity, such as women from non-endemic areas or travellers to malarious areas, infection is associated with high risks of severe disease with maternal and perinatal mortality. Women are at particular risk of cerebral malaria, hypoglycaemia, pulmonary oedema and severe haemolytic anaemia. Fetal and perinatal loss has been documented to be as high as 60-70% in non-immune women with malaria. Adults who are long-term residents of areas of moderate or high malaria transmission, including large parts of sub-Saharan Africa, usually have a high level of immunity to malaria. Infection is frequently asymptomatic and severe disease is uncommon. During pregnancy this immunity to malaria is altered. Infection is still frequently asymptomatic, so may go unsuspected and undetected, but is associated with placental parasitization. Malaria in pregnancy is a common cause of severe maternal anaemia and low birthweight babies, these complications being more common in primigravidae than multigravidae. Preventative strategies include regular chemoprophylaxis, intermittent preventative treatment with antimalarials and insecticide-treated bednets.
Authors:
Caroline E Shulman; Edgar K Dorman
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Transactions of the Royal Society of Tropical Medicine and Hygiene     Volume:  97     ISSN:  0035-9203     ISO Abbreviation:  Trans. R. Soc. Trop. Med. Hyg.     Publication Date:    2003 Jan-Feb
Date Detail:
Created Date:  2003-07-30     Completed Date:  2003-09-02     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7506129     Medline TA:  Trans R Soc Trop Med Hyg     Country:  England    
Other Details:
Languages:  eng     Pagination:  30-5     Citation Subset:  IM    
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK. caroline.shulman@btinternet.com
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MeSH Terms
Descriptor/Qualifier:
Anemia / complications
Antimalarials / therapeutic use
Bedding and Linens
Endemic Diseases
Female
Fetal Growth Retardation / parasitology
HIV Infections / complications
Humans
Infant, Low Birth Weight
Infant, Newborn
Insect Control
Malaria, Falciparum / congenital,  prevention & control*
Maternal Mortality
Obstetric Labor, Premature / parasitology
Poverty Areas
Pregnancy
Pregnancy Complications, Infectious / virology
Pregnancy Complications, Parasitic / prevention & control*
Prenatal Diagnosis
Travel
Chemical
Reg. No./Substance:
0/Antimalarials

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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