Document Detail


Importance of post-exercise hypotension in plasma volume restoration.
MedLine Citation:
PMID:  10848641     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to test the hypothesis that post-exercise hypotension was the mechanism for the plasma volume and albumin gain during recovery. Seven healthy young men completed two experiments (> or =1 week apart) to exercise continuously at 65% of peak aerobic capacity for 60 min followed by the recovery without (experiment 1) or with phenylephrine infusion (experiment 2) to counteract post-exercise hypotension. Heart rate, arterial pressure (Finapres), plasma volume (PV, Evans blue dye dilution), haematocrit, haemoglobin, plasma total solutes (refractometer), albumin, total proteins (colorimetric method), [Na+] and [K+] were not different prior to the experiments. Exercise decreased PV -13.7% (-521 mL) and -14.2% (-566 mL) at the end of 60 min in experiments 1 and 2, respectively, associated with increases in the concentrations of plasma albumin, total protein and solutes. These changes were similar between the two experiments. Following 30 min recovery in experiment 1 the decreased PV was not significantly different from the baseline. Although the volume restoration was complete at the end of 90 min recovery, the change in the albumin concentration was still above zero, indicating a gain of 11 g albumin (P < 0.05). When phenylephrine was infused during recovery, there was no gain in intravascular albumin associated with a sustained decrease in PV (-7% or -280 mL, P < 0.05) observed at the end of experiment 2. These data suggest that post-exercise hypotension may be the mechanism for a gain of intravascular albumin via the lymph return, which enhances plasma water retention and PV restoration during recovery from exercise induced hypovolaemia, even without rehydration.
Authors:
P M Hayes; J C Lucas; X Shi
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  169     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-06-29     Completed Date:  2000-06-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  115-24     Citation Subset:  IM    
Affiliation:
Department of Integrative Physiology, University of North Texas Health Science Center, Fort Worth 76107, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure / physiology
Dehydration / physiopathology
Heart Rate / physiology
Hematocrit
Hemoglobins
Humans
Hypotension / drug therapy,  physiopathology*
Lymph / physiology
Male
Phenylephrine / administration & dosage
Physical Exertion / physiology*
Plasma Volume / physiology*
Rest / physiology
Serum Albumin / metabolism
Vasoconstrictor Agents / administration & dosage
Grant Support
ID/Acronym/Agency:
HL 45547/HL/NHLBI NIH HHS; HL43202/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Hemoglobins; 0/Serum Albumin; 0/Vasoconstrictor Agents; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of mitogens on growth and contractile responses of rat small arteries: In vitro studies.
Next Document:  Relationships between muscle morphology and insulin sensitivity are improved after adjustment for in...