Document Detail

Importance of platelet serologic testing for defining the cause of neonatal thrombocytopenia.
MedLine Citation:
PMID:  2029082     Owner:  NLM     Status:  MEDLINE    
This report illustrates the importance of serologic techniques for defining the etiology of neonatal thrombocytopenia. In Case 1 the maternal count was low normal to normal during the first postpartum week. Several weeks later the appearance of persistent maternal thrombocytopenia led to the demonstration of anti-GP IIb-IIIa in stored and freshly obtained maternal sera, suggesting that the mother had an autoimmune type of thrombocytopenia. The mother of Case 2 had systemic lupus erythematosus. However, serologic testing revealed that the infant's thrombocytopenia was not related to the mother's lupus but was secondary to alloimmunization with the PlA1 antigen. An algorithm for defining etiologic mechanisms in infants with antibody-mediated forms of thrombocytopenia is presented.
M Pao; M G Karlowicz; T S Kickler; W H Zinkhan
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American journal of pediatric hematology/oncology     Volume:  13     ISSN:  0192-8562     ISO Abbreviation:  Am J Pediatr Hematol Oncol     Publication Date:  1991  
Date Detail:
Created Date:  1991-06-13     Completed Date:  1991-06-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7908071     Medline TA:  Am J Pediatr Hematol Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  71-6     Citation Subset:  IM    
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.
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MeSH Terms
Blood Platelets / immunology*
Infant, Newborn
Isoantibodies / analysis
Platelet Count
Thrombocytopenia / blood*,  etiology,  immunology*
Reg. No./Substance:

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