Document Detail

Importance of myocyte-nonmyocyte interactions in cardiac development and disease.
MedLine Citation:
PMID:  22461366     Owner:  NLM     Status:  MEDLINE    
Emerging data in the field of cardiac development as well as repair and regeneration indicate a complex and important interplay between endocardial, epicardial, and myofibroblast populations that is critical for cardiomyocyte differentiation and postnatal function. For example, epicardial cells have been shown to generate cardiac myofibroblasts and may be one of the primary sources for this cell lineage during development. Moreover, paracrine signaling from the epicardium and endocardium is critical for proper development of the heart and pathways such as Wnt, fibroblast growth factor, and retinoic acid signaling have been shown to be key players in this process. Despite this progress, interactions between nonmyocyte cells and cardiomyocytes in the heart are still poorly understood. We review the various nonmyocyte-myocyte interactions that occur in the heart and how these interactions, primarily through signaling networks, help direct cardiomyocyte differentiation and regulate postnatal cardiac function.
Ying Tian; Edward E Morrisey
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Circulation research     Volume:  110     ISSN:  1524-4571     ISO Abbreviation:  Circ. Res.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-30     Completed Date:  2012-07-05     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1023-34     Citation Subset:  IM    
Department of Medicine, University of Pennsylvania, PA 19104-5129, USA.
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MeSH Terms
Cell Communication / physiology*
Cell Differentiation
Cell Proliferation
Endocardium / cytology
Fibroblasts / cytology
Heart / embryology*,  physiology
Heart Diseases / physiopathology*
Myocytes, Cardiac / cytology*
Pericardium / cytology
Grant Support
R01 HL064632/HL/NHLBI NIH HHS; R01 HL064632-13/HL/NHLBI NIH HHS; R01 HL087825/HL/NHLBI NIH HHS; R01 HL087825-05/HL/NHLBI NIH HHS; U01 HL100405/HL/NHLBI NIH HHS; U01 HL100405-04/HL/NHLBI NIH HHS

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