| Importance of myocyte-nonmyocyte interactions in cardiac development and disease. | |
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MedLine Citation:
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PMID: 22461366 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Emerging data in the field of cardiac development as well as repair and regeneration indicate a complex and important interplay between endocardial, epicardial, and myofibroblast populations that is critical for cardiomyocyte differentiation and postnatal function. For example, epicardial cells have been shown to generate cardiac myofibroblasts and may be one of the primary sources for this cell lineage during development. Moreover, paracrine signaling from the epicardium and endocardium is critical for proper development of the heart and pathways such as Wnt, fibroblast growth factor, and retinoic acid signaling have been shown to be key players in this process. Despite this progress, interactions between nonmyocyte cells and cardiomyocytes in the heart are still poorly understood. We review the various nonmyocyte-myocyte interactions that occur in the heart and how these interactions, primarily through signaling networks, help direct cardiomyocyte differentiation and regulate postnatal cardiac function. |
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Authors:
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Ying Tian; Edward E Morrisey |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Circulation research Volume: 110 ISSN: 1524-4571 ISO Abbreviation: Circ. Res. Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-03-30 Completed Date: 2012-07-05 Revised Date: 2013-04-01 |
Medline Journal Info:
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Nlm Unique ID: 0047103 Medline TA: Circ Res Country: United States |
Other Details:
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Languages: eng Pagination: 1023-34 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Pennsylvania, PA 19104-5129, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Communication / physiology* Cell Differentiation Cell Proliferation Endocardium / cytology Fibroblasts / cytology Heart / embryology*, physiology Heart Diseases / physiopathology* Humans Myocytes, Cardiac / cytology* Pericardium / cytology |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL064632/HL/NHLBI NIH HHS; R01 HL064632-13/HL/NHLBI NIH HHS; R01 HL087825/HL/NHLBI NIH HHS; R01 HL087825-05/HL/NHLBI NIH HHS; U01 HL100405/HL/NHLBI NIH HHS; U01 HL100405-04/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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