| Importance of microcirculatory disturbances in the pathogenesis of pancreatitis. | |
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MedLine Citation:
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PMID: 11753796 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pancreatic microvascular control is a complex physiological process which is incompletely understood. Blood flow in the pancreas is altered by a large number of endogenous and exogenous factors in the context of acute and chronic pancreatitis. The frequency of progression from acute pancreatitis to a chronic form is a controversial question. In acute pancreatitis reductions in blood flow and alterations of microvascular integrity resulting in impaired tissue oxygenation play an important part in the progression and possibly the initiation of the disease. Endothelin and nitric oxide are believed to be two of the most effective vasoactive mediators. The beneficial effect of therapeutic strategies affecting vasoactive mediators is confirmed in experimental studies. Chronic disease is associated with decreased pancreatic blood flow and histological changes in the vasculature in both patients and animal models. Further studies are needed to clarify whether ischemia in chronic pancreatitis is more important in perpetuating the disease or as primary cause of the inflammatory processes. |
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Authors:
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D Uhlmann; S Ludwig; F Geissler; A Tannapfel; J Hauss; H Witzigmann |
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Publication Detail:
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Type: Comparative Study; Journal Article; Review |
Journal Detail:
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Title: Zentralblatt für Chirurgie Volume: 126 ISSN: 0044-409X ISO Abbreviation: Zentralbl Chir Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-12-25 Completed Date: 2002-04-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0413645 Medline TA: Zentralbl Chir Country: Germany |
Other Details:
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Languages: eng Pagination: 873-8 Citation Subset: IM |
Affiliation:
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Klinik für Abdominal, Transplantations und Gefässchirurgie der Universität Leipzig, Germany. Uhld@medizin.uni-leipzig.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Capillary Permeability Chronic Disease Endothelins / physiology Free Radicals Humans Inflammation / pathology Ischemia / complications* Microcirculation* Nitric Oxide / physiology Pancreas / blood supply* Pancreatitis / etiology*, pathology, physiopathology Pancreatitis, Acute Necrotizing / physiopathology Platelet Activating Factor / physiology Rats |
| Chemical | |
Reg. No./Substance:
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0/Endothelins; 0/Free Radicals; 0/Platelet Activating Factor; 10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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