| Importance of left ventricular longitudinal function and functional reserve in patients with degenerative mitral regurgitation: assessment by two-dimensional speckle tracking. | |
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MedLine Citation:
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PMID: 19041577 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of this study was to determine whether two-dimensional speckle tracking of longitudinal myocardial deformation can detect limited contractile reserve during exercise in patients with asymptomatic degenerative mitral regurgitation (MR). METHODS: Seventy-one patients with degenerative MR and normal left ventricular (LV) ejection fractions underwent quantitative exercise echocardiography. RESULTS: Compared with 23 normal subjects matched for age and sex, LV volumes were greater in patients with MR. At rest, global longitudinal strain (GLS) was lower in patients, indicating subclinical LV dysfunction. During exercise, the extent and the magnitude of changes in GLS were larger in controls than in patients with MR. On multivariate regression analysis, left atrial volume at rest and changes in GLS at peak exercise were independently associated with changes in LV ejection fraction. CONCLUSION: In asymptomatic patients with degenerative MR, subnormal LV function can be reliably identified by two-dimensional strain imaging. Limited exercise LV longitudinal contractile recruitment during exercise predicts postoperative LV dysfunction. |
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Authors:
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Patrizio Lancellotti; Bernard Cosyns; Dimitris Zacharakis; Emilio Attena; Guy Van Camp; Olivier Gach; Marc Radermecker; Luc A Piérard |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography Volume: 21 ISSN: 1097-6795 ISO Abbreviation: J Am Soc Echocardiogr Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-01 Completed Date: 2009-02-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8801388 Medline TA: J Am Soc Echocardiogr Country: United States |
Other Details:
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Languages: eng Pagination: 1331-6 Citation Subset: IM |
Affiliation:
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Department of Cardiology, University Hospital Sart Tilman, Liège, Belgium. plancellotti@chu.ulg.ac.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Echocardiography
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methods* Elasticity Imaging Techniques / methods* Female Fractional Flow Reserve, Myocardial* Humans Male Middle Aged Mitral Valve Insufficiency / complications*, ultrasonography* Reproducibility of Results Sensitivity and Specificity Stroke Volume Ventricular Dysfunction, Left / etiology*, ultrasonography* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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