Document Detail

Importance of left ventricular chamber size in determining the response to hydralazine in severe chronic heart failure.
MedLine Citation:
PMID:  7383109     Owner:  NLM     Status:  MEDLINE    
To examine the importance of left ventricular chamber size in determing the response to vasodilator therapy, we performed echocardiography in 40 patients with chronic refractory heart failure before they were treated with oral hydralazine. The left ventricular end-diastolic dimension (LVEDD) correlated significantly with the per cent change in stroke volume (r = 0.77), left ventricular filling pressure (r = -0.68), and stroke work index (r = 0.87) during short-term drug administration. After 14 to 21 days of maintenance therapy, 15 of 24 patients with an LVEDD greater than or equal to 60 mm were improved, and one was worse; mean blood urea nitrogen decreased from 45.6 to 30.6 mg per deciliter in the 21 patients in this group who completed the study (16.3 to 10.9 mmol per liter) (P less than 0.001). In contrast, only two of 16 patients with an LVEDD less than 60 mm improved, whereas 10 showed clinical deterioration; blood urea nitrogen increased from 49.3 to 64.2 mg per deciliter in the 13 patients in this group who completed the study (17.6 to 22.9 mmol per liter) (P less than 0.01). These findings indicate that left ventricular chamber size is an important factor in the response to hydralazine in patients with severe chronic heart failure.
M Packer; J Meller; N Medina; R Gorlin; M V Herman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The New England journal of medicine     Volume:  303     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1980 Jul 
Date Detail:
Created Date:  1980-08-28     Completed Date:  1980-08-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  250-5     Citation Subset:  AIM; IM    
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MeSH Terms
Administration, Oral
Blood Pressure
Cardiac Volume*
Chronic Disease
Heart Failure / drug therapy*,  physiopathology
Heart Ventricles / physiopathology
Hydralazine / administration & dosage,  therapeutic use*
Middle Aged
Myocardial Contraction
Stroke Volume
Vascular Resistance
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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