Document Detail

Importance of the lactate anion in control of breathing.
MedLine Citation:
PMID:  9475845     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to examine the effects of raising the arterial La- and K+ levels on minute ventilation (VE) in rats. Either La- or KCl solutions were infused in anesthetized spontaneously breathing Wistar rats to raise the respective ion arterial concentration ([La-] and [K+]) gradually to levels similar to those observed during strenuous exercise. VE, blood pressure, and heart rate were recorded continuously, and arterial [La-], [K+], pH, and blood gases were repeatedly measured from blood samples. To prevent changes in pH during the La- infusions, a solution of sodium lactate and lactic acid was used. Raising [La-] to 13.2 +/- 0.6 (SE) mM induced a 47.0 +/- 4.0% increase in VE without any concomitant changes in either pH or PCO2. Raising [K+] to 7.8 +/- 0.11 mM resulted in a 20.3 +/- 5.28% increase in VE without changes in pH. Thus our results show that La- itself, apart from lactic acidosis, may be important in increasing VE during strenuous exercise, and we confirm earlier results regarding the role of arterial [K+] in the control of VE during exercise.
T Hardarson; J O Skarphedinsson; T Sveinsson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  84     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-03-24     Completed Date:  1998-03-24     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  411-6; discussion 409-10     Citation Subset:  IM    
Department of Physiology, University of Iceland, Reykjavik, Iceland.
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MeSH Terms
Infusions, Intravenous
Lactic Acid / administration & dosage,  blood*,  pharmacology
Potassium / administration & dosage,  blood,  pharmacology
Pulmonary Gas Exchange / drug effects
Pulmonary Ventilation / drug effects,  physiology
Rats, Wistar
Respiration / drug effects,  physiology*
Reg. No./Substance:
50-21-5/Lactic Acid; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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