Document Detail


Importance of internal mammary artery perfusion in cardiac ischemia and reperfusion.
MedLine Citation:
PMID:  14714770     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Our purpose was to investigate the changes in antioxidant defense systems due to internal mammary artery (IMA) perfusion during coronary artery bypass graft (CABG) operations in which proximal anastomoses were completed under partial bypass with the aid of a side-biting clamp. MATERIAL AND METHOD: Twenty-five patients to be studied were divided into two groups according to the criterion of whether during proximal anastomoses left internal mammary artery (LIMA) perfusion was applied (n = 15, LIMA group) or not (n = 10, non-LIMA group). The erythrocyte catalase (CAT), superoxide dismutase (SOD), serum lipid peroxidation (LPO) products and whole blood reduced glutathione (GSH) levels were measured in the blood samples taken from the coronary sinus before cardiopulmonary bypass (CPB) (t1), before declamping (t2), at the 5th min after declamping (t3), at the 5th (t4) and 15th (t5) min after removing the side-biting clamp. RESULTS: While erythrocyte CAT enzyme activity decreases in both groups after the basal measurements, no significant difference was detected between the groups. Although the GSH levels did not differ at t1, t2 and t3, they were found to be higher in the LIMA group at t4 (p = 0.006) and t5 (p = 0.021). The erythrocyte SOD enzyme activity decreased after the basal measurements in both groups, but this reduction was less in the LIMA group at t4 (p = 0.034) and t5 (p = 0.018) compared to the other group. LPO products rose in both groups when reperfusion started after declamping. The levels of LPO products were significantly higher at t4 and t5 in the non-LIMA group than the other group (p = 0.011 and p = 0.008). CONCLUSION: If proximal anastomoses of coronary grafts are completed under partial bypass, permitting LIMA perfusion during this procedure will be beneficial to antioxidant defense systems.
Authors:
Turan Ege; Sevgi Eskiocak; Volkan Yuksel; Ali Taskiran; Enver Duran
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Perfusion     Volume:  18     ISSN:  0267-6591     ISO Abbreviation:  Perfusion     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2004-01-12     Completed Date:  2005-04-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8700166     Medline TA:  Perfusion     Country:  England    
Other Details:
Languages:  eng     Pagination:  351-6     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Surgery, Trakya University Medical Faculty, Edirne, Turkey. turanege@ttnet.net.tr
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MeSH Terms
Descriptor/Qualifier:
Antioxidants / metabolism*
Catalase / blood
Coronary Artery Bypass* / methods
Female
Glutathione / blood
Humans
Internal Mammary-Coronary Artery Anastomosis*
Lipid Peroxidation
Male
Middle Aged
Myocardial Ischemia*
Myocardial Reperfusion*
Superoxide Dismutase / blood
Chemical
Reg. No./Substance:
0/Antioxidants; 70-18-8/Glutathione; EC 1.11.1.6/Catalase; EC 1.15.1.1/Superoxide Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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