Document Detail

Importance of hepatic fibrosis in cystic fibrosis and the predictive value of liver biopsy.
MedLine Citation:
PMID:  21254170     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: Clinical modalities currently employed to evaluate suspected CFLD help to identify a cohort of children at risk for liver disease and adverse outcomes but do not predict an individual's risk of liver fibrosis or PHT development. Liver fibrosis on biopsy predicts the development of clinically significant liver disease. Dual passes help to address sampling concerns. Liver biopsy has a relevant role in the management of patients with suspected CFLD and deserves more widespread application.
Peter J Lewindon; Ross W Shepherd; Meagan J Walsh; Ristan M Greer; Richard Williamson; Tamara N Pereira; Kieran Frawley; Scott C Bell; Jeffery L Smith; Grant A Ramm
Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-11-17
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  53     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-21     Completed Date:  2011-03-02     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  193-201     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 American Association for the Study of Liver Diseases.
Department of Gastroenterology, Royal Children's Hospital, Brisbane, Queensland, Australia.
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MeSH Terms
Alanine Transaminase / blood
Biopsy, Needle / methods
Child, Preschool
Cystic Fibrosis / complications*,  mortality
Follow-Up Studies
Hypertension, Portal / etiology
Liver / pathology*,  ultrasonography
Liver Cirrhosis / etiology*,  pathology,  ultrasonography
Predictive Value of Tests
Prospective Studies
Young Adult
Reg. No./Substance:
EC Transaminase
Comment In:
Hepatology. 2011 May;53(5):1779-80; author reply 1780-1   [PMID:  21351113 ]
Hepatology. 2011 Mar;53(3):1064-5   [PMID:  21374682 ]

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