| Importance of hepatic fibrosis in cystic fibrosis and the predictive value of liver biopsy. | |
| | |
MedLine Citation:
|
PMID: 21254170 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
CONCLUSION: Clinical modalities currently employed to evaluate suspected CFLD help to identify a cohort of children at risk for liver disease and adverse outcomes but do not predict an individual's risk of liver fibrosis or PHT development. Liver fibrosis on biopsy predicts the development of clinically significant liver disease. Dual passes help to address sampling concerns. Liver biopsy has a relevant role in the management of patients with suspected CFLD and deserves more widespread application. |
| | |
Authors:
|
Peter J Lewindon; Ross W Shepherd; Meagan J Walsh; Ristan M Greer; Richard Williamson; Tamara N Pereira; Kieran Frawley; Scott C Bell; Jeffery L Smith; Grant A Ramm |
Publication Detail:
|
Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-11-17 |
Journal Detail:
|
Title: Hepatology (Baltimore, Md.) Volume: 53 ISSN: 1527-3350 ISO Abbreviation: Hepatology Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-01-21 Completed Date: 2011-03-02 Revised Date: 2013-05-20 |
Medline Journal Info:
|
Nlm Unique ID: 8302946 Medline TA: Hepatology Country: United States |
Other Details:
|
Languages: eng Pagination: 193-201 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 American Association for the Study of Liver Diseases. |
Affiliation:
|
Department of Gastroenterology, Royal Children's Hospital, Brisbane, Queensland, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Alanine Transaminase / blood Biopsy, Needle / methods Child Child, Preschool Cystic Fibrosis / complications*, mortality Female Follow-Up Studies Humans Hypertension, Portal / etiology Liver / pathology*, ultrasonography Liver Cirrhosis / etiology*, pathology, ultrasonography Male Predictive Value of Tests Prospective Studies Young Adult |
| Chemical | |
Reg. No./Substance:
|
EC 2.6.1.2/Alanine Transaminase |
| Comments/Corrections | |
Comment In:
|
Hepatology. 2011 May;53(5):1779-80; author reply 1780-1
[PMID:
21351113
]
Hepatology. 2011 Mar;53(3):1064-5 [PMID: 21374682 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoi...
Next Document: Activation of serotonin receptor-2B rescues small-for-size liver graft failure in mice.