Document Detail

Importance of hemoglobin concentration to exercise: acute manipulations.
MedLine Citation:
PMID:  16516566     Owner:  NLM     Status:  MEDLINE    
An acute reduction of blood hemoglobin concentration ([Hb]), even when the circulating blood volume is maintained, results in lower (.)V(O(2)(max) and endurance performance, due to the reduction of the oxygen carrying capacity of blood. Conversely, an increase of [Hb] is associated with enhanced (.)V(O(2)(max) and endurance capacity, that is also proportional to the increase in the oxygen carrying capacity of blood. The effects on endurance capacity appear more pronounced and prolonged than on (.)V(O(2)(max). During submaximal exercise, there is a tight coupling between O(2) demand and O(2) delivery, such that if [Hb] is acutely decreased muscle blood flow is increased proportionally and vice versa. During maximal exercise with either a small or a large muscle mass, neither peak cardiac output nor peak leg blood flow are affected by reduced [Hb]. An acute increase of [Hb] has no effect on maximal exercise capacity or (.)V(O(2)(max) during exercise in acute hypoxia. Likewise, reducing [Hb] in altitude-acclimatized humans to pre-acclimatization values has no effect on (.)V(O(2)(max) during exercise in hypoxia.
José A L Calbet; Carsten Lundby; Maria Koskolou; Robert Boushel
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-03-03
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  151     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-17     Completed Date:  2006-07-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  132-40     Citation Subset:  IM    
Department of Physical Education, University of Las Palmas de Gran Canaria, Spain.
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MeSH Terms
Exercise / physiology*
Hemoglobins / metabolism*
Muscle, Skeletal / physiology
Regional Blood Flow / physiology
Reg. No./Substance:

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