Document Detail

Importance of folate in human nutrition.
MedLine Citation:
PMID:  11509099     Owner:  NLM     Status:  MEDLINE    
From a public health perspective, some of the new insights into folic acid nutrition are of significance. Folate intake recommendations vary under different conditions. Intake of 350 microg is required to maintain plasma homocysteine levels, 650 microg for those with elevated plasma homocysteine, about 400 microg for women planning to become pregnant and 4000 microg for those with history of neural tube defect affected pregnancy. This raises the question whether the folate intake is adequate for the general population, particularly in the vulnerable groups or whether there is a need for scientists to take a fresh view of the requirements, recommended dietary intakes, and consider intervention measures which will have impact on the folate nutritional status. The recommendations should provide a margin of safety to allow for decreased intake, increased requirements, individual variability and bioavailability of natural food folates. The folate intake and nutriture in relation to India and other developing countries needs careful consideration to reduce anemia, neural tube defects and possibly impact on the high incidence of cardiovascular diseases.
K Krishnaswamy; K Madhavan Nair
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The British journal of nutrition     Volume:  85 Suppl 2     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-08-17     Completed Date:  2001-08-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  S115-24     Citation Subset:  IM    
National Institute of Nutrition, Jamai-Osmania, Hyderabad-500007, India.
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MeSH Terms
Biological Availability
Birth Weight
Cardiovascular Diseases / etiology
Folic Acid / administration & dosage,  physiology*
Folic Acid Deficiency / complications,  epidemiology*
Homocysteine / blood
India / epidemiology
Intestinal Absorption
Liver / embryology,  metabolism
Neoplasms / etiology
Neural Tube Defects / etiology
Nutrition Policy*
Nutritional Physiological Phenomena
Public Health*
Reg. No./Substance:
454-28-4/Homocysteine; 59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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