Document Detail

Importance of fiberoptic bronchoscopy in identifying asthma phenotypes to direct personalized therapy.
MedLine Citation:
PMID:  23197289     Owner:  NLM     Status:  In-Data-Review    
PURPOSE OF REVIEW: This review summarizes the phenotyping of refractory asthma with an emphasis on how direct bronchoscopic observation and analysis of bronchoalveolar lavage (BAL), biopsy, and brushings of the airways helps direct specific personalized therapy. Additional testing used in phenotyping asthmatic patients is reviewed.
RECENT FINDINGS: Several studies and publications over the past decade have emphasized the importance of phenotyping refractory asthmatic patients to offer a better understanding of the pathobiology of disease. Bronchoscopy is a useful tool in phenotyping asthma with objective data obtained from BAL, endobronchial biopsy, and brushings. Phenotyping asthma with bronchoscopy affords personalized and successful therapy.
SUMMARY: By using fiberoptic bronchoscopy, specific asthma phenotypes can be identified: laryngopharyngeal reflux with silent aspiration; subacute bacterial infection; tissue eosinophilia; a combination of two or three of these; and nonspecific. Identifying these phenotypes and personalizing therapy with bronchoscopy leads to improved outcomes.
Steven E Lommatzsch; Richard J Martin; James T Good
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current opinion in pulmonary medicine     Volume:  19     ISSN:  1531-6971     ISO Abbreviation:  Curr Opin Pulm Med     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9503765     Medline TA:  Curr Opin Pulm Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  42-8     Citation Subset:  IM    
Divisions of Pulmonary and Critical Care Medicine, Department of Medicine, National Jewish Health, University of Colorado Denver, Denver, Colorado, USA.
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