Document Detail

Importance of the Omp25/Omp31 family in the internalization and intracellular replication of virulent B. ovis in murine macrophages and HeLa cells.
MedLine Citation:
PMID:  18457973     Owner:  NLM     Status:  MEDLINE    
The role of the outer membrane proteins of the Omp25/Omp31 family in invasiveness and intracellular survival of virulent B. ovis in phagocytes was analyzed. The absence of Omp25d or Omp22 in B. ovis abolished its invasive capacity in HeLa cells and reduced it in J774.A1 cells. Additionally, in J774.A1 cells, the Deltaomp25d mutant was unable to multiply, whereas the Deltaomp22 mutant was cleared at 24h post-infection. These findings demonstrate that Omp25d and Omp22 are essential for the invasion and survival of B. ovis inside host cells, and justify the strong attenuation in virulence of the Deltaomp25d and Deltaomp22 mutants.
Ana I Martín-Martín; Paola Caro-Hernández; Antonio Orduña; Nieves Vizcaíno; Luis Fernández-Lago
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-03-10
Journal Detail:
Title:  Microbes and infection / Institut Pasteur     Volume:  10     ISSN:  1286-4579     ISO Abbreviation:  Microbes Infect.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-06-02     Completed Date:  2008-08-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883508     Medline TA:  Microbes Infect     Country:  France    
Other Details:
Languages:  eng     Pagination:  706-10     Citation Subset:  IM    
Departamento de Microbiología y Genética, Edificio Departamental, Universidad de Salamanca, Plaza Doctores de la Reina s/n, 37007 Salamanca, Spain.
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MeSH Terms
Bacterial Outer Membrane Proteins / genetics,  physiology*
Brucella ovis / physiology*
Brucellosis / microbiology
Hela Cells / microbiology*
Macrophages / microbiology*
Reg. No./Substance:
0/Bacterial Outer Membrane Proteins

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