Document Detail

Importance of ductus venosus Doppler assessment for fetal outcome in cases of intrauterine growth restriction.
MedLine Citation:
PMID:  15192295     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The measurement and evaluation of ductus venosus (DV) blood flow velocity waveform in high-risk pregnancies has been studied intensively in recent years in order to find a more intermediate signal of fetal compromise. Our objective was to study the fetal outcome of pregnancies with intrauterine growth retardation (IUGR) and normal pulsatility of DV compared to an IUGR group with increased DV pulsatility. METHODS: The outcome of 42 fetuses before 32 weeks of gestational age without chromosomal or structural aberrations was analyzed. All fetuses showed IUGR <5th percentile based on placental insufficiency diagnosed by pathologic RI >90th percentile of both maternal uterine arteries. One group (30 fetuses; mean weight 730 g/SD 190 g; mean gestational age 197 days/SD 12 days) showed normal, the other (12 fetuses, mean weight 675 g/SD 179 g; mean gestational age 198 days/SD 12 days) reduced, but neither absent nor reverse DV flow during atrial contraction. All 42 fetuses were delivered by cesarean section because of severe variable or prolonged decelerations. We measured blood flow velocities of the DV in every fetus on an average 3.7 days (range 1-5 days) before cesarean section. Fetal outcome was determined by Apgar scores after 5 and 10 min, arterial pH and base excess; neonatal morbidity was recorded by intensive follow-up. RESULTS: There were no significant differences of pH, umbilical artery base excess, Apgar scores and severe neonatal complications between the two groups. CONCLUSIONS: Our own data show no correlation between increased pulsatility in the DV (without absent or reverse flow during atrial contraction) and fetal outcome before 32 gestational weeks, even in cases of severe growth restriction based on placental insufficiency. Therefore in these cases reduced DV flow during atrial contraction should cautiously be interpreted regarding obstetrical decisions.
Stefan Ritter; Hendrik Jörn; Claudia Weiss; Werner Rath
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  19     ISSN:  1015-3837     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:    2004 Jul-Aug
Date Detail:
Created Date:  2004-06-11     Completed Date:  2005-01-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  348-55     Citation Subset:  IM    
Copyright Information:
Copyright 2004 S. Karger AG, Basel
Department of Obstetrics and Gynecology, Rhine-Westphalian Technical University (RWTH), Aachen, Germany.
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MeSH Terms
Blood Flow Velocity / physiology
Confidence Intervals
Fetal Growth Retardation / ultrasonography*
Fetus / blood supply*
Infant, Newborn
Placental Circulation / physiology
Pregnancy Outcome / epidemiology
Ultrasonography, Doppler, Color / methods,  statistics & numerical data*
Ultrasonography, Prenatal / methods,  statistics & numerical data*

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