Document Detail


Importance of drug delivery system in steroid aerosol therapy via nebulizer.
MedLine Citation:
PMID:  12406667     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aim of our study was to evaluate if the type of nebulizer can influence the effects of steroid aerosol therapy. We considered 27 asthmatics allergic to grasses with FEV1<80% of the predictive value or methacholine PD20 FEV1<750 mcg. The patients were divided into three groups in relation to the type of nebulizer they used and treated 9 weeks by aerosol therapy with beclomethasone dipropionate bid (800 mcg). Respect to the values recorded at the beginning and at the end of the therapy we found different variations of spirometric indeces and PD20 values among the three groups. We can conclude that the type of nebulizer influences steroid aerosol therapy and, particularly, jet nebulizers seem more efficient than ultrasonic nebulizers.
Authors:
C Terzano; L Allegra
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Pulmonary pharmacology & therapeutics     Volume:  15     ISSN:  1094-5539     ISO Abbreviation:  Pulm Pharmacol Ther     Publication Date:  2002  
Date Detail:
Created Date:  2002-10-30     Completed Date:  2003-02-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9715279     Medline TA:  Pulm Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  449-54     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular and Respiratory Sciences, University La Sapienza, Rome, Italy. eterzano@tin.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Albuterol / administration & dosage
Animals
Anti-Asthmatic Agents / administration & dosage*
Asthma / drug therapy*
Beclomethasone / administration & dosage*
Bronchoconstrictor Agents / administration & dosage
Bronchodilator Agents / administration & dosage
Drug Delivery Systems / classification*
Female
Forced Expiratory Flow Rates
Forced Expiratory Volume
Humans
Male
Methacholine Chloride / administration & dosage
Mites / immunology
Nebulizers and Vaporizers / classification*
Peak Expiratory Flow Rate
Spirometry
Chemical
Reg. No./Substance:
0/Anti-Asthmatic Agents; 0/Bronchoconstrictor Agents; 0/Bronchodilator Agents; 18559-94-9/Albuterol; 4419-39-0/Beclomethasone; 62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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