Document Detail

Importance of diet in protection against oxidative damage.
MedLine Citation:
PMID:  17159793     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: In humans, epidemiological evidence suggests that increased consumption of fruits and vegetables can substantially enhance the protection against many common types of cancer. METHODS & RESULTS: A molecular epidemiological study in 3 Slovak factories producing asbestos, glass fibres and rockwool was conducted. Altogether 388 subjects (239 exposed, 148 controls) were investigated. Food frequency questionnaire was used to ascertain nutrient intake and compared to plasma levels of selected micronutrients, as well as to markers of oxidative stress (MDA, oxidative DNA damage and DNA repair) and antioxidant protection. We found a negative correlation between MDA concentrations and consumption of fruits (p=0.05) and vegetables (p=0.05) in all control subjects. Intake of fruits (p=0.05), vegetables (p=0.01), milk (p=0.01) and cereals (p=0.05) inversely correlated with oxidative DNA damage (net FPG) in all subjects investigated. There was a negative correlation between the intake of fruits (p=0.05) and vegetables (p=0.01) in all exposed subjects. CONCLUSIONS: Our results suggest that well balanced food consumption with higher fruits and vegetables intake has a protective effect against oxidative damage.
Marta Staruchová; Katarína Volková; Alica Lajdová; Csilla Misl'anová; Andrew Collins; Ladislava Wsólová; Ladislav Staruch; Mária Dusinská
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuro endocrinology letters     Volume:  27 Suppl 2     ISSN:  0172-780X     ISO Abbreviation:  Neuro Endocrinol. Lett.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-25     Completed Date:  2007-06-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008373     Medline TA:  Neuro Endocrinol Lett     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  112-5     Citation Subset:  IM    
Research Base of Slovak Medical University, Bratislava, Slovakia.
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MeSH Terms
Aged, 80 and over
DNA Damage*
Malondialdehyde / blood
Middle Aged
Mineral Fibers / toxicity
Occupational Diseases / prevention & control
Oxidative Stress*
Vitamins / blood
Reg. No./Substance:
0/Mineral Fibers; 0/Vitamins; 542-78-9/Malondialdehyde

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