Document Detail


Importance of dermal blood supply and epidermis on the transdermal iontophoretic delivery of monovalent cations.
MedLine Citation:
PMID:  7658349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of dermal blood flow on the transdermal iontophoresis of five monovalent cationic solutes has been investigated using an in vivo rat model. The iontophoretic flux of solutes from topical application sites was shown, using anesthetized and sacrificed rats, to be independent of the dermal blood supply. The presence of a viable blood supply significantly affected the extent of penetration of solutes into deeper underlying tissues during iontophoresis. Higher tissue concentrations of solutes were found in the upper tissue layers of sacrificed rats, with no blood supply, compared to those in anesthetized rats. In all animals the highest concentration of solute after 2 h iontophoresis was found in the epidermis. Iontophoretic application of solutes to skin with the epidermis removed resulted in significantly lower fluxes than from sites where the skin was intact. These findings suggest that local blood flow determines systemic and underlying tissue solute absorption but not epidermal penetration fluxes during iontophoretic delivery. Finally, the dependence of iontophoretic transport of a solute on the solute's size in vivo was similar to relationships previously reported for excised human skin studies.
Authors:
S E Cross; M S Roberts
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  84     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-10-02     Completed Date:  1995-10-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  584-92     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia.
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Animals
Ethanolamine
Ethanolamines / administration & dosage,  pharmacokinetics
Glucosamine / administration & dosage,  pharmacokinetics
Iontophoresis*
Lidocaine / administration & dosage,  pharmacokinetics
Mathematics
Phenethylamines / administration & dosage,  pharmacokinetics
Rats
Rats, Inbred Strains
Regional Blood Flow
Skin / blood supply*,  drug effects
Sodium / administration & dosage,  pharmacokinetics
Time Factors
Chemical
Reg. No./Substance:
0/Ethanolamines; 0/Phenethylamines; 137-58-6/Lidocaine; 141-43-5/Ethanolamine; 3416-24-8/Glucosamine; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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