Document Detail

Importance of congestive heart failure and interaction of congestive heart failure and left ventricular systolic function on prognosis in patients with acute myocardial infarction.
MedLine Citation:
PMID:  8914875     Owner:  NLM     Status:  MEDLINE    
Left ventricular (LV) systolic function and congestive heart failure (CHF) are important predictors of long-term mortality after acute myocardial infarction. The importance of transient CHF and the interaction of CHF and LV function on prognosis has not been studied in detail previously. In the TRAndolapril Cardiac Evaluation Study, 6,676 consecutive patients with acute myocardial infarction 1 to 6 days earlier had LV systolic function quantified as wall motion index (echocardiography), which is closely correlated to LV ejection fraction. To study the interaction of CHF and wall motion index on long-term mortality, separate analyses were performed in patients with different levels of LV function. Risk ratio (95% confidence intervals [CI]) were determined from proportional hazard models subgrouped by wall motion index or CHF adjusted for age and gender. Heart failure was separated into transient or persistent. Wall motion index and CHF are correlated. Furthermore, there is an interaction between wall motion index and CHF. The prognostic importance of wall motion index depends on whether patients have CHF or not: the risk ratio associated with decreasing 1 wall motion index unit is 3.0 (2.6 to 3.4) in patients with CHF, and 2.2 (1.7 to 2.9) in patients without CHF when adjusted for age and gender. Similarly, the prognostic importance of CHF depends on the level of wall motion index: the risk ratio associated with CHF is 3.9 (1.8 to 8.3) when the wall motion index is <0.8 and 1.9 (1.5 to 2.3) when the wall motion index is >1.6. Transient CHF is an independent risk factor (risk ratio 1.5, confidence interval [CI] 1.3 to 1.8) although milder than persistent CHF (risk ratio 2.8, CI 2.5 to 3.2).
L Køber; C Torp-Pedersen; O D Pedersen; S Høiberg; A J Camm
Related Documents :
21301185 - Limited role of auxiliary endobronchial biopsy in the diagnosis of japanese patients wi...
20641105 - Clinical significance of awake oscillatory ventilation in patients with heart failure a...
6499855 - Permanent cardiac pacing in congenital heart disease: a follow-up study of 20 patients.
21447965 - Increased s-nitrosothiol levels in nonasthmatic eosinophilic bronchitis compared with c...
3693855 - Intratendinous ruptures of the flexor digitorum profundus tendon of the small finger.
7626575 - Long term ocular and neurological involvement in severe congenital toxoplasmosis.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  78     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-01-02     Completed Date:  1997-01-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1124-8     Citation Subset:  AIM; IM    
Department of Cardiology P, Gentofte University Hospital of Copenhagen, Denmark.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Confidence Intervals
Heart Failure / complications,  mortality,  physiopathology*
Middle Aged
Multivariate Analysis
Myocardial Infarction / complications,  mortality,  physiopathology*
Proportional Hazards Models
Retrospective Studies
Risk Factors
Stroke Volume
Survival Rate
Systole / physiology*
Ventricular Function, Left / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Comparison of quantitation of left ventricular volume, ejection fraction, and cardiac output in pati...
Next Document:  Rationale, background, and design of the randomized angiotensin receptor antagonist--angiotensin-con...