| Importance of congenital cytomegalovirus infections as a cause for pre-lingual hearing loss. | |
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MedLine Citation:
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PMID: 16384744 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: No large population based studies of newborn hearing screening have reported the population frequency of more than one specific form of deafness. OBJECTIVES: To combine available data on the overall incidence of pre-lingual deafness with estimates for specific causes to gain insight into age-related changes in the prevalence of the major causes of pre-lingual deafness. STUDY DESIGN: The incidence of deafness in England was adjusted for the exclusion of unilateral losses to obtain an overall estimate of 1.86 per 1000 births in the United States. Longitudinal data were used to estimate that the prevalence rises to 2.70 per 1000 at age 4. The genetic component was estimated sentinel phenotype analysis, and studies of single entities were integrated to estimate the prevalence of specific causes. RESULTS AND CONCLUSIONS: Congenital CMV infections and connexin mutations are the two major causes of deafness at birth, while causes for enlarged vestibular aqueduct along with congenital CMV infection are the major causes of pre-lingual hearing loss that is not expressed at birth. By molecular screening tests on newborn blood spots for four known causes, 60% of the infants who develop late onset pre-lingual hearing loss could be identified at birth. |
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Authors:
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Walter E Nance; B Gail Lim; Kelley M Dodson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2005-12-27 |
Journal Detail:
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Title: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology Volume: 35 ISSN: 1386-6532 ISO Abbreviation: J. Clin. Virol. Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-01-10 Completed Date: 2006-03-30 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9815671 Medline TA: J Clin Virol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 221-5 Citation Subset: IM |
Affiliation:
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Department of Human Genetics and Otolaryngology, Virginia Commonwealth University, Richmond, VA 23298, USA. nance@hsc.vcu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cytomegalovirus Infections
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complications*,
congenital Deafness / classification, etiology*, genetics Hearing Loss, Sensorineural / classification, etiology*, genetics Hearing Tests / statistics & numerical data* Humans Infant, Newborn |
| Grant Support | |
ID/Acronym/Agency:
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1 R01 DC04239/DC/NIDCD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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