Document Detail

Importance of clean-up for comparison of TEQ-values obtained by CALUX and chemo-analysis.
MedLine Citation:
PMID:  18969557     Owner:  NLM     Status:  In-Data-Review    
This paper presents Chemically Activated LUciferine gene eXpression (CALUX) TEQ-values obtained for nine plasma samples following two different purification procedures, one of them involving fractionation. CALUX results obtained for the dioxin (DX) and dioxin + PCB (DX + PCB) fractions were then compared to the GC-HRMS TEQ-values calculated for the 17 polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (17 PCDD/F) and 17 PCDD/F + 4 cPCB congeners, respectively. The overestimation of the CALUX (DX fraction) TEQ-values in comparison with the chemo-analyses of the 17 PCDD/F is mainly explained by the presence of other AhR agonists, like brominated compounds. Otherwise, the constancy of the CALUX (DX + PCB fraction) TEQ-value which compares to increasing the GC-HRMS (17 PCDD/F + 4 cPCB) TEQ results raises questions concerning (1) the significance of CALUX results obtained without fractionation as well as (2) the toxicological effect of a cocktail of contaminants on the human health.
N Van Wouwe; I Windal; H Vanderperren; G Eppe; C Xhrouet; E De Pauw; L Goeyens; W Baeyens
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Talanta     Volume:  63     ISSN:  1873-3573     ISO Abbreviation:  Talanta     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2008-10-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984816R     Medline TA:  Talanta     Country:  England    
Other Details:
Languages:  eng     Pagination:  1269-72     Citation Subset:  -    
Scientific Institute of Public Health, 14 J. Wytsman Street, Brussels B-1050, Belgium.
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