| Importance of blood pressure control in left ventricular mass regression. | |
| | |
MedLine Citation:
|
PMID: 20980215 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Blood pressure (BP) reduction to 140/90 mm Hg or lower using renin-angiotensin-system blockers reportedly provides the greatest left ventricular (LV) mass regression; β-blockers have less effect. This study examined whether combination antihypertensive therapy would provide greater benefit. With a double-blind, parallel-group design, the effects of 3 different combinations, carvedilol controlled-release (CR)/lisinopril, atenolol/lisinopril, and lisinopril, on left ventricular mass index (LVMI) were assessed by MRI after 12 months. Patients were treated to achieve guideline-recommended BP (<140 mm Hg/<90 mm Hg; diabetes: <130 mm Hg/<80 mm Hg). Sample size was calculated to achieve 90% power to detect a 5 g/m(2) difference in mean change from baseline in LVMI between the carvedilol CR/lisinopril group and each of the other treatment groups. Of 287 patients randomized, more than 50% were titrated to maximum dosage; 73% reached targeted BP. At month 12 (last observation carried forward ≥ month 9) for 195 evaluable subjects, mean BP was similar in all groups (carvedilol CR/lisinopril: 128.8/77.9; atenolol/lisinopril: 128.7/76.5; lisinopril: 126.3/80.3 mm Hg). Compared with baseline, mean LVMI decreased to a similar extent in all groups (carvedilol CR/lisinopril: -6.3; atenolol/lisinopril: -6.7; lisinopril: -7.9 g/m(2)). Achievement of targeted BP control is more important than treatment regimen in achieving LV mass reduction. |
| | |
Authors:
|
Alan B Miller; Nathaniel Reichek; Martin St John Sutton; Malini Iyengar; Linda S Henderson; Elizabeth A Tarka; George L Bakris |
Related Documents
:
|
6278905 - Prediction of sustained antihypertensive efficacy of chronic captopril therapy: relatio... 2677375 - The effects of indomethacin and sulindac upon the blood pressures of individuals with u... 10824365 - Does combination therapy with a calcium channel blocker and an ace inhibitor have addit... 11939615 - Pulse pressure and diurnal blood pressure variation: association with micro- and macrov... 11992865 - Resolution of papilledema after neurosurgical decompression for primary chiari i malfor... 352185 - Continuous positive pressure ventilation in children with bronchopneumonia. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-27 |
Journal Detail:
|
Title: Journal of the American Society of Hypertension : JASH Volume: 4 ISSN: 1933-1711 ISO Abbreviation: J Am Soc Hypertens Publication Date: 2010 Nov-Dec |
Date Detail:
|
Created Date: 2010-12-06 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101312518 Medline TA: J Am Soc Hypertens Country: United States |
Other Details:
|
Languages: eng Pagination: 302-10 Citation Subset: IM |
Copyright Information:
|
2010 American Society of Hypertension. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Division of Cardiology, Department of Medicine, University of Florida, Jacksonville, Florida 32209, USA. alan.miller@jax.ufl.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Renal dysfunction impairs circadian variation of endothelial function in patients with essential hyp...
Next Document: The relation between blood pressure changes induced by passive leg raising and arterial stiffness.