Document Detail


Importance of ancillary properties of beta blockers in angina: a study of celiprolol and atenolol.
MedLine Citation:
PMID:  2899439     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Celiprolol (400 mg) and atenolol (100 mg) were given once a day to 16 patients with stable angina pectoris in a double blind placebo controlled crossover study. Celiprolol produced less suppression of heart rate both at rest and during exercise than atenolol. Both drugs were equally effective in reducing the frequency of angina and in delaying the onset of ischaemia during exercise. Radionuclide ventriculography showed that atenolol but not celiprolol lowered cardiac output at rest and during exercise. Thus the ancillary properties of celiprolol, including partial beta 2 agonist activity and direct vasodilating activity, have detectable effects on cardiac function that may be beneficial in patients with angina.
Authors:
J M McLenachan; J T Wilson; H J Dargie
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British heart journal     Volume:  59     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-09-02     Completed Date:  1988-09-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  685-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Cardiology, Western Infirmary, Glasgow.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / therapeutic use*
Adult
Aged
Angina Pectoris / drug therapy*,  physiopathology
Atenolol / therapeutic use*
Blood Pressure / drug effects
Celiprolol
Clinical Trials as Topic
Depression, Chemical
Double-Blind Method
Female
Heart Rate / drug effects
Hemodynamics / drug effects
Humans
Male
Middle Aged
Physical Exertion
Propanolamines / therapeutic use*
Random Allocation
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Propanolamines; 29122-68-7/Atenolol; 56980-93-9/Celiprolol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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