Document Detail

Importance of airway inflammation for late asthmatic reactions induced by toluene diisocyanate in sensitized subjects.
MedLine Citation:
PMID:  2823559     Owner:  NLM     Status:  MEDLINE    
To determine the importance of airway inflammation for late asthmatic reactions and increased airway responsiveness induced by TDI, we investigated whether late asthmatic reactions and increased responsiveness induced by TDI are associated with airway inflammation and whether steroids prevent them by modifying the inflammatory response within the airways. We measured FEV1 before and at regular intervals after exposure to TDI and performed dose-response curves to methacholine and bronchoalveolar lavage 8 hr after TDI in two subjects with previously documented late asthmatic reaction; then we repeated the same procedure a few weeks after treatment with steroids. Airway responsiveness and polymorphonuclear cells were increased in both subjects after the late asthmatic reaction; treatment with steroids prevented late asthmatic reaction and the increase in airway responsiveness and polymorphonuclear cells in bronchoalveolar lavage. These results suggest that late asthmatic reaction induced by TDI may be caused by airway inflammation.
P Boschetto; E Zocca; O Bruchi; G Cappellazzo; G F Milani; F Pivirotto; C E Mapp; L M Fabbri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Advances in prostaglandin, thromboxane, and leukotriene research     Volume:  17B     ISSN:  0732-8141     ISO Abbreviation:  Adv. Prostaglandin Thromboxane Leukot. Res.     Publication Date:  1987  
Date Detail:
Created Date:  1987-11-25     Completed Date:  1987-11-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8211444     Medline TA:  Adv Prostaglandin Thromboxane Leukot Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1080-4     Citation Subset:  IM    
Institute of Occupational Medicine, University of Padua, Italy.
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MeSH Terms
Asthma / etiology*
Cyanates / adverse effects*
Inflammation / etiology
Methacholine Chloride
Methacholine Compounds / pharmacology
Respiratory System / drug effects
Time Factors
Toluene 2,4-Diisocyanate / adverse effects*
Reg. No./Substance:
0/Cyanates; 0/Methacholine Compounds; 584-84-9/Toluene 2,4-Diisocyanate; 62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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