| Importance of aggressive blood pressure lowering when it may matter most. | |
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MedLine Citation:
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PMID: 17666192 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Variation in blood pressure levels follows a reproducible circadian pattern, characterized by low levels during sleep and a rapid increase during the early-morning period. The incidence of cardiovascular events displays a similar circadian variation, with peak occurrence coinciding with the early-morning blood pressure surge. Numerous prospective studies have shown that blood pressure measured over a 24-hour period is superior to clinic blood pressure in predicting future cardiovascular events. Thus, the use of ambulatory blood pressure monitoring (ABPM) to identify patients at risk of cardiovascular events could improve the management of the patient with hypertension. ABPM has also become widely adopted to evaluate antihypertensive therapeutic options that might provide blood pressure reduction throughout the 24-hour dosing interval. Recently, community-based trials have shown that it is feasible to perform ABPM-oriented research in nonresearch environments. This allows us to better understand the efficacy of antihypertensive therapies in a "real-world" setting. Studies of this nature can even assess blood pressure control in the early-morning period by sequestering data before and after awakening. |
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Authors:
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William B White |
Publication Detail:
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Type: Journal Article; Review Date: 2007-05-25 |
Journal Detail:
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Title: The American journal of cardiology Volume: 100 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-08-01 Completed Date: 2007-09-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 10J-16J Citation Subset: AIM; IM |
Affiliation:
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Division of Hypertension and Clinical Pharmacology, Pat and Jim Calhoun Cardiology Center, University of Connecticut School of Medicine, Farmington, Connecticut 06032-3940, USA. wwhite@nsol.uchc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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administration & dosage,
therapeutic use* Blood Pressure / physiology Blood Pressure Monitoring, Ambulatory Circadian Rhythm Decision Trees Humans Hypertension / drug therapy*, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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