Document Detail

Importance of the adrenergic nerve system in the response of gases in the arterial blood following the provoked bronchospasm.
MedLine Citation:
PMID:  23097963     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: This work, partial pressure of the respiratory gases in the capillary blood (pH, PaO2, PaCO2) was studied, following the protective action of the beta2-drenergic stimulator-Hexoprenaline and alpha2-adrenergic blocker-Tolazoline in the bronchoconstriction caused by a beta-blocker-Propranolol.
MATERIAL AND METHODS: in patients with increased bronchial reactibility. pH, oxygen partial pressure (PaO2), dioxide carbon partial pressure (PaCO2) in the arterial blood, with the assistance of the analyzer IL, following some minutes of sample taking were defined in all patients. As a standard to verify the accuracy of the measurement, ampoule solutions of pH, PaO2 and PaCO2 were utilized (Acidobasel, Berlin).
RESULTS AND DISCUSSION: Following the inhalation of the beta-blocker-Propranolol (20 mg/ml-aerosol), there was an evident decrease (p < 0.05) of pO2 and a non-significant increase (p > 0.1) of pCO2. Beta2-adrenergcic stimulator-Hexoprenaline (2 inh x 0.2 mg), shows an protective effect in the decrease of pO2 (p < 0.05) following the bronchoconstriction being provoked by Propranolol. Alpha2-adrenergic blocker-Tolazoline (20 mg/ml-aerosol), has not shown a protective action in the bronchoconstriction caused with propranolol, therefore significant decrease (p < 0.05) of pO2 and a non-significant increase (p > 0.1) of pCO2 appeared. This shows that stimulation of beta2-adrenergic receptor has protective action in changes of the respiratory gases. Meantime, blocker of the alpha2-adrenergic receptor (Tolazoline) has not shown a protective action in changes of the respiratory gases.
Hilmi Islami; Arta Veseli; Emir Behluli; Naim Morina
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical archives (Sarajevo, Bosnia and Herzegovina)     Volume:  66     ISSN:  0350-199X     ISO Abbreviation:  Med Arch     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-26     Completed Date:  2012-12-05     Revised Date:  2014-07-07    
Medline Journal Info:
Nlm Unique ID:  101635337     Medline TA:  Med Arch     Country:  Bosnia and Hercegovina    
Other Details:
Languages:  eng     Pagination:  292-5     Citation Subset:  IM    
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MeSH Terms
Adrenergic alpha-Antagonists / pharmacology
Adrenergic beta-2 Receptor Agonists
Adrenergic beta-Antagonists / pharmacology
Bronchial Spasm / physiopathology*
Carbon Dioxide / blood*
Hexoprenaline / pharmacology
Oxygen / blood*
Partial Pressure
Propranolol / pharmacology
Pulmonary Disease, Chronic Obstructive / physiopathology
Pulmonary Gas Exchange
Receptors, Adrenergic / physiology*
Tolazoline / pharmacology
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Adrenergic beta-2 Receptor Agonists; 0/Adrenergic beta-Antagonists; 0/Receptors, Adrenergic; 142M471B3J/Carbon Dioxide; 9Y8NXQ24VQ/Propranolol; CHH9H12AQ3/Tolazoline; G9L6B3W684/Hexoprenaline; S88TT14065/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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