| Importance of multi-lineage hematologic involvement and hypoalbuminemia at diagnosis in patients with "risk-organ" multi-system Langerhans cell histiocytosis. | |
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MedLine Citation:
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PMID: 20418784 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To perform a risk factor analysis in patients with "risk organ" multi-system Langerhans cell histiocytosis at diagnosis. METHODS: From 1987 to 2007, 77 patients were analyzed. A univariate analysis of the variables, age <2 years, lungs, spleen and hepatic involvement, presence of >or=2 risk involved organs, hypoalbuminemia and the presence of isolated anemia, anemia with thrombocytopenia with or without leukopenia at diagnosis was performed. Statistically significant variables were combined and entered into a multivariate analysis. RESULTS: Fifty-six and 66 evaluable patients had hematologic and hepatic involvement at diagnosis, respectively. Among the hematologic patients, the subgroup of anemia with thrombocytopenia with or without leukopenia showed a significantly lower 5-year survival than the subgroup of isolated anemia (0.19 vs. 0.87, respectively; P=0.0001). Of all the patients, those with hypoalbuminemia had a 5-year survival of 0.16 compared with those with normal albumin levels, who had a 5-year survival of 0.65 (P<0.0001). In multivariate analysis, only anemia with thrombocytopenia with or without leukopenia and hypoalbuminemia were the independent risk factors (relative risk 3.77; confidence interval, 1.7-8.4; P<0.0011 and relative risk 2.59; confidence interval, 1.24-5.4; P<0.0112). CONCLUSIONS: Anemia with thrombocytopenia with or without leukopenia and hypoalbuminemia, were associated with worse prognosis in multi-system Langerhans cell histiocytosis. Other therapeutic strategies should be considered at diagnosis or early during the initial treatment for this high risk subgroup of patients. |
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Authors:
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Jorge Luis Braier; Diego Rosso; Antonio Latella; Guillermo Chantada; Blanca Ozuna; Mario Ripoli; Marcelo Scopinaro |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pediatric hematology/oncology Volume: 32 ISSN: 1536-3678 ISO Abbreviation: J. Pediatr. Hematol. Oncol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-07 Completed Date: 2010-05-27 Revised Date: 2011-10-06 |
Medline Journal Info:
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Nlm Unique ID: 9505928 Medline TA: J Pediatr Hematol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: e122-5 Citation Subset: IM |
Affiliation:
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Department of Hematology/Oncology, Hospital Nacional de Pediatría Juan P Garrahan, University of Buenos Aires, Buenos Aires, Argentina. jolubraier@gmail.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Age Factors Anemia / complications, mortality, pathology* Cell Lineage* Child Child, Preschool Female Histiocytosis, Langerhans-Cell / complications, diagnosis*, mortality Humans Hypoalbuminemia / complications, mortality, pathology* Infant Infant, Newborn Leukopenia / complications, mortality, pathology* Male Risk Factors Survival Rate Thrombocytopenia / complications, mortality, pathology* Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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