Document Detail


Importance of IL-18-induced super Th1 cells for the development of allergic inflammation.
MedLine Citation:
PMID:  20414054     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Th1 cells, which express IL-18R, produce IFN-gamma in response to Ag and IL-2 and increase further production of IFN-gamma upon additional IL-18 stimulation. They simultaneously produce Th2 cytokines (IL-9 and IL-13), GM-CSF and chemokines (RANTES, MIP-1alpha). Human Th1 cells also produce IFN-gamma and IL-13 in response to anti-CD3 and IL-18. Recently, we demonstrated Th1 cells induce intrinsic type atopic asthma and dermatitis by production of Th1- and Th2-cytokines and chemokines. Here, we review the pathological roles of Th1 cells, stimulated with Ag and IL-18 in vivo, in the pathogenesis of allergic disorders by production of Th1 and Th2 cytokines and chemokines. Based on this unique function of Ag- plus IL-18-stimulated Th1 cells, we proposed to designate them as "super Th1 cells".
Authors:
Kenji Nakanishi; Hiroko Tsutsui; Tomohiro Yoshimoto
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-04-24
Journal Detail:
Title:  Allergology international : official journal of the Japanese Society of Allergology     Volume:  59     ISSN:  1440-1592     ISO Abbreviation:  Allergol Int     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-27     Completed Date:  2010-09-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9616296     Medline TA:  Allergol Int     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  137-41     Citation Subset:  IM    
Affiliation:
Department of Immunology and Medical Zoology, Hyogo College of Medicine, Hyogo, Japan. nakaken@hyo-med.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Allergens / immunology
Animals
Anti-Allergic Agents / pharmacology,  therapeutic use
Asthma / complications,  drug therapy,  genetics,  immunology*
Genetic Association Studies
Humans
Infection / complications,  drug therapy,  genetics,  immunology*
Inflammation
Interleukin-18 / genetics,  immunology*
Lymphocyte Activation / genetics
Models, Immunological
Polymorphism, Genetic
Receptors, Interleukin-18 / antagonists & inhibitors,  immunology*
Th1 Cells / immunology*
Chemical
Reg. No./Substance:
0/Allergens; 0/Anti-Allergic Agents; 0/Interleukin-18; 0/Receptors, Interleukin-18

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