Document Detail


Importance of HLA antigen splits for kidney transplant matching.
MedLine Citation:
PMID:  2898695     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Whether matching for HLA antigen "splits" results in better transplant outcome than matching for "broad" HLA antigens was investigated in 30,000 first cadaver kidney transplants. At three years, there was an 18% difference between the survival rates of grafts with 0 or 4 mismatches among transplants typed for HLA-A and B antigen splits whereas the difference in transplants typed for broad antigens was only 2%. Analysis of HLA-A, B antigens together with HLA-DR antigens showed an even greater advantage of matching for antigen splits: the difference in survival at three years between grafts with 0 or 6 mismatches for HLA-A, B, DR was 31% when antigen splits were analysed, in contrast to a 6% difference with broad antigens. These results indicate that typing for HLA antigen splits is important in renal transplantation, that the potential benefit of HLA matching in renal transplantation is greater than currently accepted, and that HLA typing and kidney allocation routines must be refined in order to exploit this potential.
Authors:
G Opelz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lancet     Volume:  2     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-08-11     Completed Date:  1988-08-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  61-4     Citation Subset:  AIM; IM    
Affiliation:
Department of Transplantation Immunology, University of Heidelberg, Federal Republic of Germany.
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MeSH Terms
Descriptor/Qualifier:
Cadaver
Cyclosporins / administration & dosage
Graft Survival
HLA Antigens / analysis*
HLA-DR Antigens / analysis
Histocompatibility Testing*
Humans
Immunosuppression
Kidney Transplantation*
Chemical
Reg. No./Substance:
0/Cyclosporins; 0/HLA Antigens; 0/HLA-DR Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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