Document Detail

Importance of early postnatal weight gain for normal retinal angiogenesis in very preterm infants: a multicenter study analyzing weight velocity deviations for the prediction of retinopathy of prematurity.
MedLine Citation:
PMID:  22491391     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess WINROP (, an algorithm using postnatal weight measurements, as a tool for the prediction of retinopathy of prematurity (ROP) in a large geographically and racially diverse study population.
METHODS: WINROP analysis was performed retrospectively on conventionally at-risk infants from 10 neonatal intensive careunits.Weight measurements were entered into WINROP, which signals an alarm for an abnormal weight gain rate. Infants were classified into categories of no alarm (unlikely to develop type 1ROP)and alarm (at risk for developing type 1ROP).Use of WINROP requires that an infant has (1) gestational age less than 32 weeks at birth, (2) weekly weight measurements,(3) physiologic weight gain,and(4)absence of other pathologic retinal vascular disease.
RESULTS: A total of 1706 infants with a median gestational age of 28 weeks (range, 22-31 weeks) and median birth weight of 1016 g (range, 378-2240 g) were included in the study analysis. An alarm occurred in 1101 infants (64.5%), with a median time from birth to alarm of 3 weeks (range, 0-12 weeks) and from alarm to treatment of 8 weeks (range, 1 day to 22 weeks). The sensitivity of WINROP was 98.6% and the negative predictive value was 99.7%. Two infants with type 1 ROP requiring treatment after 40 weeks' postmenstrual age did not receive an alarm.
CONCLUSION: The WINROP system is a useful adjunct for ROP screening that identifies high-risk infants early to optimize care and potentially reduce the overall number of diagnostic ROP examinations.
Carolyn Wu; Chatarina Löfqvist; Lois E H Smith; Deborah K VanderVeen; Ann Hellström;
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Validation Studies    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  130     ISSN:  1538-3601     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-10-11     Completed Date:  2012-10-30     Revised Date:  2014-06-17    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  992-9     Citation Subset:  AIM; IM    
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MeSH Terms
Birth Weight*
False Positive Reactions
Gestational Age
Infant, Newborn
Infant, Very Low Birth Weight
Intensive Care Units, Neonatal
Predictive Value of Tests
Retinal Neovascularization / classification,  diagnosis*
Retinal Vessels / pathology*
Retinopathy of Prematurity / classification,  diagnosis*
Retrospective Studies
Sensitivity and Specificity
Weight Gain*
Grant Support
R01 EY017017/EY/NEI NIH HHS; R01 EY022275/EY/NEI NIH HHS
Ann Hellström / ; Chatarina Löfqvist / ; Lois E H Smith / ; Deborah K VanderVeen / ; Carolyn Wu / ; Kristi Cumming / ; Kimberly Dresner / ; Lisa Faia / ; Camilia R Martin / ; Reshma Mehendale / ; Caroline Cromelin / ; Amy K Hutchinson / ; Ben H Lee / ; Michael H Brent / ; Patrick Santiago / ; Mark Barsamian / ; Don Bremer / ; Rae Fellows / ; David A Bateman / ; Michael F Chiang / ; Eva Nong / ; John S Hartmann / ; M Elizabeth Hartnett / ; Frank Bednarek / ; Frank J McCabe / ; Jill B Whelan / ; R Gary Lane /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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