| Importance of the Difference in Surface Pressures of the Cell Membrane in Doxorubicin Resistant Cells That do not Express Pgp and ABCG2. | |
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MedLine Citation:
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PMID: 23314884 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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P-glycoprotein (Pgp) represents the archetypal mechanism of drug resistance. But Pgp alone cannot expel drugs. A small but growing body of works has demonstrated that the membrane biophysical properties are central to Pgp-mediated drug resistance. For example, a change in the membrane surface pressure is expected to support drug-Pgp interaction. An interesting aspect from these models is that under specific conditions, the membrane is predicted to take over Pgp concerning the mechanism of drug resistance especially when the surface pressure is high enough, at which point drugs remain physically blocked at the membrane level. However it remains to be determined experimentally whether the membrane itself could, on its own, affect drug entry into cells that have been selected by a low concentration of drug and that do not express transporters. We demonstrate here that in the case of the drug doxorubicin, alteration of the surface pressure of membrane leaflets drive drug resistance. |
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Authors:
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Charlotte Bell; Claire Hill; Christopher Burton; Adam Blanchard; Freya Shephard; Cyril Rauch |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-13 |
Journal Detail:
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Title: Cell biochemistry and biophysics Volume: - ISSN: 1559-0283 ISO Abbreviation: Cell Biochem. Biophys. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9701934 Medline TA: Cell Biochem Biophys Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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University of Birmingham, School of Medicine and Dentistry, Edgbaston, Birmingham, B15 2TT, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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