| Importance of B cell co-stimulation in CD4(+) T cell differentiation: X-linked agammaglobulinaemia, a human model. | |
| | |
MedLine Citation:
|
PMID: 21488866 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We were interested in the question of whether the congenital lack of B cells actually had any influence on the development of the T cell compartment in patients with agammaglobulinaemia. Sixteen patients with X-linked agammaglobulinaemia (XLA) due to mutations in Btk, nine patients affected by common variable immune deficiency (CVID) with <2% of peripheral B cells and 20 healthy volunteers were enrolled. The T cell phenotype was determined with FACSCalibur and CellQuest Pro software. Mann-Whitney two-tailed analysis was used for statistical analysis. The CD4 T cell memory compartment was reduced in patients with XLA of all ages. This T cell subset encompasses both CD4(+)CD45RO(+) and CD4(+)CD45RO(+)CXCR5(+) cells and both subsets were decreased significantly when compared to healthy controls: P = 0·001 and P < 0·0001, respectively. This observation was confirmed in patients with CVID who had <2% B cells, suggesting that not the lack of Bruton's tyrosine kinase but the lack of B cells is most probably the cause of the impaired CD4 T cell maturation. We postulate that this defect is a correlate of the observed paucity of germinal centres in XLA. Our results support the importance of the interplay between B and T cells in the germinal centre for the activation of CD4 T cells in humans. |
| | |
Authors:
|
H Martini; V Enright; M Perro; S Workman; J Birmelin; E Giorda; I Quinti; V Lougaris; M Baronio; K Warnatz; B Grimbacher |
Related Documents
:
|
1813016 - Proliferation of peripheral lymphocytes to interleukin-2 and interleukin-4 after marrow... 2004356 - Identification of a co-stimulatory factor for human t cell proliferation. 21334716 - Cd5(-) diffuse large b-cell lymphoma with peculiar cyclin d1+ phenotype. pathologic and... 21335336 - Laminar shear stress delivers cell cycle arrest and anti-apoptosis to mesenchymal stem ... 3668006 - Natural cell-mediated cytotoxicity in vitiligo. 2659116 - Effects of anti-myeloid antibodies on the generation of hematopoietic colony-forming un... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2011-04-13 |
Journal Detail:
|
Title: Clinical and experimental immunology Volume: 164 ISSN: 1365-2249 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-05-03 Completed Date: 2011-07-18 Revised Date: 2013-05-24 |
Medline Journal Info:
|
Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
|
Languages: eng Pagination: 381-7 Citation Subset: IM |
Copyright Information:
|
© 2011 The Authors. Clinical and Experimental Immunology © 2011 British Society for Immunology. |
Affiliation:
|
Department of Immunology, Royal Free Hospital and University College London, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Agammaglobulinemia / diagnosis, genetics, immunology Antigens, CD45 / biosynthesis B-Lymphocytes / immunology, metabolism*, pathology CD4-Positive T-Lymphocytes / immunology, metabolism*, pathology Cell Differentiation Cell Separation Child Common Variable Immunodeficiency / diagnosis, genetics, immunology* Female Flow Cytometry Genetic Diseases, X-Linked / diagnosis, genetics, immunology Humans Immunologic Memory Lymphocyte Depletion Male Middle Aged Mutation / genetics Protein-Tyrosine Kinases / genetics Receptors, CXCR5 / biosynthesis |
| Chemical | |
Reg. No./Substance:
|
0/CXCR5 protein, human; 0/Receptors, CXCR5; EC 2.7.10.1/Agammaglobulinaemia tyrosine kinase; EC 2.7.10.1/Protein-Tyrosine Kinases; EC 3.1.3.48/Antigens, CD45 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intrathecal neuromedin U induces biphasic effects on sympathetic vasomotor tone, increases respirato...
Next Document: Activation of coagulation in bullous pemphigoid and other eosinophil-related inflammatory skin disea...