Document Detail


Import of peroxisomal matrix and membrane proteins.
MedLine Citation:
PMID:  10966464     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This review summarizes the progress made in our understanding of peroxisome biogenesis in the last few years, during which the functional roles of many of the 23 peroxins (proteins involved in peroxisomal protein import and peroxisome biogenesis) have become clearer. Previous reviews in the field have focussed on the metabolic functions of peroxisomes, aspects of import/biogenesis the role of peroxins in human disease, and involvement of the endoplasmic reticulum in peroxisome membrane biogenesis as well as the degradation of this organelle. This review refers to some of the earlier work for the sake of introduction and continuity but deals primarily with the more recent progress. The principal areas of progress are the identification of new peroxins, definition of protein-protein interactions among peroxins leading to the recognition of complexes involved in peroxisomal protein import, insight into the biogenesis of peroxisomal membrane proteins, and, of most importance, the elucidation of the role of many conserved peroxins in human disease. Given the rapid progress in the field, this review also highlights some of the unanswered questions that remain to be tackled.
Authors:
S Subramani; A Koller; W B Snyder
Related Documents :
2674724 - A 42k outer-membrane protein is a component of the yeast mitochondrial protein import s...
3663174 - Induction of functional uncoupling protein in guinea pigs infused with noradrenaline. s...
17705834 - Identification of novel proteins affected by rotenone in mitochondria of dopaminergic c...
16600294 - Thermal adaptation of the yeast mitochondrial hsp70 system is regulated by the reversib...
21656854 - Snare protein expression in synaptic terminals and astrocytes in the adult hippocampus:...
19953544 - Comparative analysis of the secretory proteome of human adipose stromal vascular fracti...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Annual review of biochemistry     Volume:  69     ISSN:  0066-4154     ISO Abbreviation:  Annu. Rev. Biochem.     Publication Date:  2000  
Date Detail:
Created Date:  2000-12-12     Completed Date:  2000-12-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985150R     Medline TA:  Annu Rev Biochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  399-418     Citation Subset:  IM    
Affiliation:
Department of Biology, University of California, San Diego, La Jolla, California 92093-0322, USA. ssubramani@ucsd.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Biological Transport, Active
Humans
Membrane Proteins / genetics,  metabolism*
Models, Biological
Mutation
Peroxisomal Disorders / genetics,  metabolism
Peroxisomes / genetics,  metabolism*
Grant Support
ID/Acronym/Agency:
DK41737/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Membrane Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Protein tyrosine kinase structure and function.
Next Document:  Platelet-activating factor and related lipid mediators.