Document Detail

Implicit memory in Alzheimer's disease.
MedLine Citation:
PMID:  7650098     Owner:  NLM     Status:  MEDLINE    
While patients with Huntington's disease (HD) and Korsakoff's syndrome (KS) demonstrate "preserved" performance on implicit word-stem completion tasks, patients with Alzheimer's disease (AD) are typically found to be impaired. It has been hypothesized that AD patients do poorly as a result of degenerative changes in posterior cortical association areas thought to mediate performance on this type of implicit memory task, and that the relative sparing of these areas in KS and HD results in their "preserved" performance. The present study was undertaken to examine the implicit memory performance of AD patients on this task after equating their explicit performance to that of normal controls by manipulating the number of encoding exposures. When this was accomplished, the implicit memory performance of AD patients was equivalent to that of controls. The results are discussed within the context of a critical review of the evidence for the existence of separable neural systems in mediating implicit and explicit memory.
C Randolph; M C Tierney; T N Chase
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of clinical and experimental neuropsychology     Volume:  17     ISSN:  1380-3395     ISO Abbreviation:  J Clin Exp Neuropsychol     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-09-28     Completed Date:  1995-09-28     Revised Date:  2008-04-14    
Medline Journal Info:
Nlm Unique ID:  8502170     Medline TA:  J Clin Exp Neuropsychol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  343-51     Citation Subset:  IM    
Department of Psychiatry, Northwestern University Medical School, Chicago, IL 60611, USA.
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MeSH Terms
Alzheimer Disease / physiopathology,  psychology*
Mental Recall* / physiology
Nerve Net / physiopathology
Neuropsychological Tests
Paired-Associate Learning / physiology
Verbal Learning* / physiology

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