Document Detail

Implications for urgent transfusion of uncrossmatched blood in the emergency department: The prevalence of clinically significant red cell antibodies within different patient groups.
MedLine Citation:
PMID:  12786645     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To define the prevalence of alloantibodies as a factor of age and underlying clinical disease, with particular relevance to the prediction of the safety of uncrossmatched blood in different demographic groups. METHODS: A retrospective review was conducted of all immunohaematological studies on blood samples submitted to the blood bank of a tertiary referral hospital between January 1998 and December 1999. RESULTS: A total of 27 968 antibody screens in 15 966 patients were analysed. When only clinically significant antibodies were considered, the total alloimmunization prevalence was 1.9% and the prevalence of antibodies capable of causing an immediate transfusion reaction was 0.6%. The prevalence of antibodies capable of causing an immediate transfusion reaction was 0.1% in the under 30 years of age group. Clinically significant antibodies were found in 5.1% in the haematology and oncology unit patients. The risk rises with age and female sex. CONCLUSION: We conclude that uncrossmatched blood is associated with low risk in patients < 30 years of age. The knowledge that patients have not been exposed to previous transfusion or pregnancy will reduce the risk even further.
Josobel Saverimuttu; Tony Greenfield; Irene Rotenko; John Crozier; Bin Jalaludin; Michael Harvey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Emergency medicine (Fremantle, W.A.)     Volume:  15     ISSN:  1035-6851     ISO Abbreviation:  Emerg Med (Fremantle)     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-05     Completed Date:  2003-11-10     Revised Date:  2005-02-07    
Medline Journal Info:
Nlm Unique ID:  9421464     Medline TA:  Emerg Med (Fremantle)     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  239-43     Citation Subset:  IM    
Haematology Department, Liverpool Hospital, South Western Area Pathology Service, University of New South Wales, New South Wales, Australia.
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MeSH Terms
Age Factors
Autoantibodies / blood*,  immunology
Blood Grouping and Crossmatching* / adverse effects
Blood Transfusion*
Emergency Medical Services*
Erythrocytes / immunology*
Isoantibodies / blood*
Middle Aged
Retrospective Studies
Risk Factors
Reg. No./Substance:
0/Autoantibodies; 0/Isoantibodies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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