Document Detail


Implications of memory modulation for post-traumatic stress and fear disorders.
MedLine Citation:
PMID:  23354388     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Post-traumatic stress disorder, panic disorder and phobia manifest in ways that are consistent with an uncontrollable state of fear. Their development involves heredity, previous sensitizing experiences, association of aversive events with previous neutral stimuli, and inability to inhibit or extinguish fear after it is chronic and disabling. We highlight recent progress in fear learning and memory, differential susceptibility to disorders of fear, and how these findings are being applied to the understanding, treatment and possible prevention of fear disorders. Promising advances are being translated from basic science to the clinic, including approaches to distinguish risk versus resilience before trauma exposure, methods to interfere with fear development during memory consolidation after a trauma, and techniques to inhibit fear reconsolidation and to enhance extinction of chronic fear. It is hoped that this new knowledge will translate to more successful, neuroscientifically informed and rationally designed approaches to disorders of fear regulation.
Authors:
Ryan G Parsons; Kerry J Ressler
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-28
Journal Detail:
Title:  Nature neuroscience     Volume:  16     ISSN:  1546-1726     ISO Abbreviation:  Nat. Neurosci.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-28     Completed Date:  2013-03-22     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  9809671     Medline TA:  Nat Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  146-53     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / pathology,  physiopathology
Extinction, Psychological
Fear / psychology
Humans
Learning
Memory / physiology*
Nerve Net / pathology,  physiopathology
Neural Pathways / pathology,  physiopathology
Panic Disorder* / pathology,  physiopathology,  psychology
Phobic Disorders* / pathology,  physiopathology,  psychology
Stress Disorders, Post-Traumatic* / pathology,  physiopathology,  psychology
Grant Support
ID/Acronym/Agency:
F32MH090700/MH/NIMH NIH HHS; P51RR000165/RR/NCRR NIH HHS; R01 MH071537/MH/NIMH NIH HHS; R01 MH094757/MH/NIMH NIH HHS; R01 MH096764/MH/NIMH NIH HHS; R01MH071537/MH/NIMH NIH HHS; R01MH094757/MH/NIMH NIH HHS; R01MH096764/MH/NIMH NIH HHS
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