| Implications of memory modulation for post-traumatic stress and fear disorders. | |
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MedLine Citation:
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PMID: 23354388 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Post-traumatic stress disorder, panic disorder and phobia manifest in ways that are consistent with an uncontrollable state of fear. Their development involves heredity, previous sensitizing experiences, association of aversive events with previous neutral stimuli, and inability to inhibit or extinguish fear after it is chronic and disabling. We highlight recent progress in fear learning and memory, differential susceptibility to disorders of fear, and how these findings are being applied to the understanding, treatment and possible prevention of fear disorders. Promising advances are being translated from basic science to the clinic, including approaches to distinguish risk versus resilience before trauma exposure, methods to interfere with fear development during memory consolidation after a trauma, and techniques to inhibit fear reconsolidation and to enhance extinction of chronic fear. It is hoped that this new knowledge will translate to more successful, neuroscientifically informed and rationally designed approaches to disorders of fear regulation. |
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Authors:
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Ryan G Parsons; Kerry J Ressler |
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Publication Detail:
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Type: Journal Article Date: 2013-01-28 |
Journal Detail:
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Title: Nature neuroscience Volume: 16 ISSN: 1546-1726 ISO Abbreviation: Nat. Neurosci. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9809671 Medline TA: Nat Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 146-53 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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