Document Detail

Implications of maternal nutrient restriction in transgenerational programming of hypertension and endothelial dysfunction across F1-F3 offspring.
MedLine Citation:
PMID:  22365957     Owner:  NLM     Status:  Publisher    
AIMS: An extensive variety of prenatal insults are associated with an increased incidence of metabolic and cardiovascular disorders in adult life. We previously demonstrated that maternal global nutrient restriction during pregnancy leads to increased blood pressure and endothelial dysfunction in the adult offspring. This study aimed to assess whether prenatal exposure to nutritional insult has transgenerational effects in F(2) and F(3) offspring. MAIN METHODS: For this, female Wistar rats were randomly divided into two groups on day 1 of pregnancy: a control group fed standard chow ad libitum and a restricted group fed 50% of the ad libitum intake throughout gestation. At delivery, all animals were fed a standard laboratory chow diet. At 11weeks of age, one female and one male from each restricted litter were randomly selected and mated with rats from another restricted litters in order to generate the F(2) offspring. The same procedure produced F(3) generation. Similarly, the rats in the control group were bred for each generation. KEY FINDINGS: Our findings show that the deleterious effects of maternal nutrient restriction to which the F(0) mothers were exposed may not be limited to the male first generation. In fact, we found that elevated blood pressure, an impaired vasodilatory response to acetylcholine and alterations in NO production were all transferred to the subsequent males from F(2) and F(3) generations. SIGNIFICANCE: Our data show that global nutrient restriction during pregnancy results in a specific phenotype that can be passed transgenerationally to a second and third generation.
Beatriz Felice Ponzio; Maria Helena Catelli Carvalho; Zuleica Bruno Fortes; Maria do Carmo Franco
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-16
Journal Detail:
Title:  Life sciences     Volume:  -     ISSN:  1879-0631     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
Nephrology Division, Medicine Department, Federal University of São Paulo (UNIFESP/EPM), Brazil.
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