Document Detail


Implications of ketogenic diet on weight gain, motor activity and cicatrization in Wistar rats.
MedLine Citation:
PMID:  23038986     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract The ketogenic diet (KD) was initially developed for the treatment of pharmacoresistant epilepsy and a possible alternative for the obesity treatment, dyslipidemia, resistance to insulin, and non-alcoholic steatosis. However, few studies evaluate the changes on the behavior, motor activity, and anxiety. The objective of this work was to analyze the influence of the ketogenic diet on the weight gain and emotional behavior of the rats submitted to experimental models such as Elevated Plus Maze (EPM) and Open Field (OF), the cicatrization time, and leukocyte differentiations was also observed. 20 male wistar rats of two months of age were divided into two groups. One was submitted to ketogenic diet (KDG) and the control group (Co) which was fed on commercial rations. After seven days the animals were weighed and submitted to EPM and OF. A small surgical incision was made and their blood was collected to count and leukocyte differentiation. It was verified that the rats from the KDG presented less weight gain as compared to the rats from the Co (p<0,05). The KDG didn't reveal differences on the behavior measures in the EPM model, but in the OF presented an ambulatory activity significantly bigger. The animals from the KDG presented a cicatrization significantly better than Co after 72 hours (p=0,0035) and 96 hours (p<0,1). There was no difference between the groups as to the count and leukocyte differentiations. In this study the results suggests that the KD can interfere on a positive way with the activity of the immune system.
Authors:
Rogério Corrêa Peres; Danilo Barion Nogueira; Gabriela de Paula Guimarães; Elizabete Lourenço da Costa; Daniel Araki Ribeiro
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-6
Journal Detail:
Title:  Toxicology mechanisms and methods     Volume:  -     ISSN:  1537-6524     ISO Abbreviation:  Toxicol. Mech. Methods     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101134521     Medline TA:  Toxicol Mech Methods     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Universidade Católica de Santos (Catholic University of Santos), Centro de Ciências da Saúde, Av. Conselheiro Nébias, 300, Vila Mathias, Santos-SP, Brazil. CEP: 11015-002.
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