| Implications of a first trimester Down's syndrome screening programme on timing of malformation detection. | |
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MedLine Citation:
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PMID: 21504413 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective. To determine the impact which introduction of the 11-14 week scan has had on the gestational age at which fetal malformations are detected by ultrasound in an unselected population of pregnant women. Design: Retrospective study. Setting: University hospital, Copenhagen, Denmark, covering the period 1.1.2003-30.6.2007. Population: All pregnant women who chose a nuchal translucency scan at 11-14 weeks for Down's syndrome risk estimate, and a scan at 18-20 weeks to screen for fetal malformations. Method: Review of cases detected ante- and postnatally. Main outcome measures. Detection rates at 11-14 weeks relative to all malformations in the population. Results. A total of 216 anomalies were detected in 200 fetuses among the 9 324 fetuses included, while 70 anomalies were diagnosed in 59 infants postnatally. The prevalence of fetuses with anomalies was 2.8% (259/9 324). After excluding cases of pyelectasis (127), which may be considered physiological and transitory changes, the prevalence of malformed fetuses was 1.4% (132/9324). Of the malformations detected antenatally, 25.8% were detected before week 15 and 59.6% in weeks 16-22. The remaining 14.6% of malformations were discovered after week 22. Among the lethal malformations 50% were diagnosed before week 15. Conclusion: Although the purpose of the first trimester scan is to screen for Down's syndrome and not for malformations, the introduction of the 11-14 week scan has resulted in the detection of approximately 26% of fetal malformations. |
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Authors:
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Tanja Roien Jakobsen; Kirsten Søgaard; Ann Tabor |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-19 |
Journal Detail:
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Title: Acta obstetricia et gynecologica Scandinavica Volume: - ISSN: 1600-0412 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370343 Medline TA: Acta Obstet Gynecol Scand Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 The Authors AOGS© 2011 Nordic Federation of Societies of Obstetrics and Gynecology. |
Affiliation:
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Department of Fetal Medicine 4002, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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