Document Detail


Implications of a first trimester Down's syndrome screening programme on timing of malformation detection.
MedLine Citation:
PMID:  21504413     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective. To determine the impact which introduction of the 11-14 week scan has had on the gestational age at which fetal malformations are detected by ultrasound in an unselected population of pregnant women. Design: Retrospective study. Setting: University hospital, Copenhagen, Denmark, covering the period 1.1.2003-30.6.2007. Population: All pregnant women who chose a nuchal translucency scan at 11-14 weeks for Down's syndrome risk estimate, and a scan at 18-20 weeks to screen for fetal malformations. Method: Review of cases detected ante- and postnatally. Main outcome measures. Detection rates at 11-14 weeks relative to all malformations in the population. Results. A total of 216 anomalies were detected in 200 fetuses among the 9 324 fetuses included, while 70 anomalies were diagnosed in 59 infants postnatally. The prevalence of fetuses with anomalies was 2.8% (259/9 324). After excluding cases of pyelectasis (127), which may be considered physiological and transitory changes, the prevalence of malformed fetuses was 1.4% (132/9324). Of the malformations detected antenatally, 25.8% were detected before week 15 and 59.6% in weeks 16-22. The remaining 14.6% of malformations were discovered after week 22. Among the lethal malformations 50% were diagnosed before week 15. Conclusion: Although the purpose of the first trimester scan is to screen for Down's syndrome and not for malformations, the introduction of the 11-14 week scan has resulted in the detection of approximately 26% of fetal malformations.
Authors:
Tanja Roien Jakobsen; Kirsten Søgaard; Ann Tabor
Related Documents :
6726703 - Influence of work during pregnancy on fetal weight.
3091643 - Fetal weight estimates in late pregnancy with emphasis on macrosomia.
17015243 - Induced abortion and unintended pregnancy in guatemala.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-19
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  -     ISSN:  1600-0412     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors AOGS© 2011 Nordic Federation of Societies of Obstetrics and Gynecology.
Affiliation:
Department of Fetal Medicine 4002, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Dysbindin-containing complexes and their proposed functions in brain: from zero to (too) many in a d...
Next Document:  Restless legs syndrome in pregnancy is a frequent disorder with a good prognosis.