Document Detail


Implications of disorders of purine metabolism for the kidney and the urinary tract.
MedLine Citation:
PMID:  24529     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The spectrum of kidney and urinary tract disorders related to purines comprises acute hyperuricosuric nephropathy, chronic urate nephropathy and urolithiasis. Two factors in the development of acute hyperuricosuric nephropathy are increased uric acid concentration and low pH in the tubular fluid. Chronic urate nephropathy still possess several problems: incidence (although this seems to be decreasing, presumably owing to effective prevention), the source of interstitial urate, the cause of the interstitial deposition of urate, and the role of urate deposits in the pathogenesis of the interstitial nephropathy. The relation of the experimental nephropathy to the pathogenesis of chronic urate nephropathy in the human is not yet clear but a model is proposed according to which interstitial urate derives from two sources: hyperuricaemic plasma and hyperuricosuric tubular fluid. Urolithiasis related to purines leads to uric acid-urate stones, xanthine stones, 2,8-dihydroxyadenine stones, iatrogenic xanthine and oxipurinol stones, and possibly calcium stones. Pathogenetic factors in uric acid lithiasis are hyperuricosuria (whether due to an inborn enzyme abnormality or of unknown aetiology) and low urinary pH; oliguria is a contributory factor. There remain several open questions about uric acid lithiasis: incidence, the shift of its location from lower to upper urinary tract, the interplay of pathogenetic factors, and the role of compounds which inhibit crystallization.
Authors:
A de Vries; O Sperling
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Ciba Foundation symposium     Volume:  -     ISSN:  0300-5208     ISO Abbreviation:  Ciba Found. Symp.     Publication Date:  1977  
Date Detail:
Created Date:  1978-05-24     Completed Date:  1978-05-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0356636     Medline TA:  Ciba Found Symp     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  179-206     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenine Phosphoribosyltransferase / deficiency
Allopurinol / therapeutic use
Animals
Calcium / metabolism
Gout / metabolism
Humans
Hydrogen-Ion Concentration
Hypoxanthine Phosphoribosyltransferase / deficiency
Kidney Calculi / epidemiology,  metabolism
Kidney Diseases / metabolism*,  physiopathology
Kidney Failure, Chronic / metabolism
Oxypurinol / metabolism
Purines / metabolism*
Sodium / metabolism
Solubility
Uric Acid / metabolism*
Urologic Diseases / metabolism*
Xanthine Oxidase / deficiency
Xanthines / metabolism
Chemical
Reg. No./Substance:
0/Purines; 0/Xanthines; 2465-59-0/Oxypurinol; 315-30-0/Allopurinol; 69-93-2/Uric Acid; 7440-23-5/Sodium; 7440-70-2/Calcium; EC 1.17.3.2/Xanthine Oxidase; EC 2.4.2.7/Adenine Phosphoribosyltransferase; EC 2.4.2.8/Hypoxanthine Phosphoribosyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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