Document Detail


Implications of body fat distribution in an older twin population.
MedLine Citation:
PMID:  10536647     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: As people age, fat becomes preferentially deposited in the abdominal region over the periphery, and such changes are thought to be associated with adverse metabolic outcomes. We were interested in whether body mass index (BMI) and waist-hip ratio (WHR) are differentially associated with fasting insulin levels, triglycerides, and blood pressure (systolic and diastolic) in an older population. We were also interested in whether these associations change after controlling for genetic influences. METHODS: Data were obtained as part of the Swedish Adoption/Twin Study of Aging. All blood samples and anthropometric measures were assessed from 1989-1991 except insulin, which was assessed from 1986-1988. The sample contains 263 twin pairs (97 monozygotic and 166 dizygotic), 56% women, average age 65 years. RESULTS: In men and women, WHR and BMI were significantly associated with all the metabolic variables except for diastolic blood pressure. When BMI's association with the metabolic variables was assessed independent of WHR, it remained significantly associated with all metabolic variables except diastolic blood pressure in men and triglycerides in women. When WHR's association with the metabolic variables was assessed independent of BMI, it did not remain significantly associated with any of the metabolic variables in men and remained significantly associated with insulin and diastolic pressure in women. After controlling for genetic effects, the relationship between WHR and the metabolic variables became nonsignificant. However, BMI remained significantly associated with systolic blood pressure and triglycerides in men, independent of WHR. CONCLUSION: The results suggest that overall body fat is important to consider in relation to these metabolic parameters in older individuals. The results also suggest that BMI may share associations with blood pressure and triglycerides beyond those that can be attributed to familial influences.
Authors:
T L Nelson; G P Vogler; N L Pedersen; Y Hong
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Twin Study    
Journal Detail:
Title:  The journals of gerontology. Series A, Biological sciences and medical sciences     Volume:  54     ISSN:  1079-5006     ISO Abbreviation:  J. Gerontol. A Biol. Sci. Med. Sci.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-11-10     Completed Date:  1999-11-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9502837     Medline TA:  J Gerontol A Biol Sci Med Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  M446-50     Citation Subset:  AIM; IM    
Affiliation:
Department of Biobehavioral Health, Pennsylvania State University, USA.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / physiology*
Adoption
Aged
Aged, 80 and over
Aging / physiology*
Blood Pressure / physiology
Body Constitution
Body Mass Index*
Female
Humans
Insulin / blood
Male
Middle Aged
Triglycerides / blood
Twins, Dizygotic
Twins, Monozygotic
Grant Support
ID/Acronym/Agency:
AG-04563/AG/NIA NIH HHS; AG-10175/AG/NIA NIH HHS; AG-1430/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Triglycerides; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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