Document Detail


Implications of RNA Helicases in HIV-1 replication: Possible roles in latency.
MedLine Citation:
PMID:  22211663     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
HAART treatment has greatly improved life expectancy of HIV-1-infected individuals. Unfortunately, latency still remains the major barrier towards HIV-1 eradication. Efforts to identify viral and host cell proteins involved in latency remain important research areas to win this war against HIV-1. Here, we review the contributions of several factors in the establishment of latently infected cells. In addition, we also raise the possibility that RNA helicases, while playing important roles at almost every step of the HIV-1 replication cycle, could be implicated in the processes governing the establishment of these latent reservoirs.
Authors:
Lara Ajamian; Andrew J Mouland
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-30
Journal Detail:
Title:  Current HIV research     Volume:  -     ISSN:  1873-4251     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-1-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101156990     Medline TA:  Curr HIV Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Lady Davis Institute for Medical Research-Sir Mortimer B. Davis Jewish General Hospital Montréal Québec H3T 1E2 Canada. ANDREW.MOULAND@MCGILL.CA.
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